Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 8/20 | 0.75 |
| ▸ | KDR | P35968 | 8/20 | 0.75 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.56 |
| ▸ | EGFR | P00533 | 7/20 | 0.53 |
| ▸ | FLT4 | P35916 | 4/20 | 0.53 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.52 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.52 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.52 |
| ▸ | RET | P07949 | 2/20 | 0.51 |
| ▸ | KIF5B | P33176 | 1/20 | 0.50 |
| ▸ | EHMT2 | Q96KQ7 | 3/20 | 0.49 |
| ▸ | EHMT1 | Q9H9B1 | 3/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | BCR | P11274 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6098042 | 0.93 | KDR (0.72) | FLT1KDRFGFR1EGFRFLT4 | |
| SCHEMBL6096842 | 0.91 | FLT1 (0.61) | FLT1KDRFGFR1EGFRFLT4 | |
| SCHEMBL6431147 | 0.87 | FLT1 (0.75) | FLT1KDRFGFR1EGFRFLT4 | |
| Hydrochloric Acid SCHEMBL6432102 | 0.87 | FLT1 (0.73) | FLT1KDRFGFR1EGFRFLT4 | |
| SCHEMBL6097880 | 0.86 | KDR (1.00) | FLT1KDRFGFR1EGFRFLT4 | |
| Hydrochloric Acid SCHEMBL6095874 | 0.86 | KDR (0.73) | FLT1KDRFGFR1EGFRFLT4 | |
| SCHEMBL5245396 | 0.85 | KDR (0.83) | FLT1KDRFGFR1EGFRFLT4 | |
| SCHEMBL6097412 | 0.84 | KDR (0.58) | FLT1KDRFGFR1EGFRFLT4 | |
| SCHEMBL6431449 | 0.80 | FLT1 (0.71) | FLT1KDRFGFR1EGFRFLT4 | |
| SCHEMBL5025550 | 0.80 | EHMT2 (0.58) | FLT1KDRFGFR1EGFRFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7087602-B2 | Cinnoline derivatives and use as medicine | ASTRAZENECA UK LIMITED (GB) | 2006-08-08 | — | — | US | disclosed |
| EP-0888310-B1 | CINNOLINE DERIVATIVES AND USE AS MEDICINE | ASTRAZENECA AB (SE) | 2005-09-07 | — | — | EP | disclosed |
| US-20030199513-A1 | Cinnoline derivatives and use as medicine | ZENECA LIMITED | 2003-10-23 | — | — | US | disclosed |
| US-6514971-B1 | For use in the production of antiangiogenic and/or vascular permeability reducing effects in warm-blooded animals such as humans | ZENECA LIMITED (GB) | 2003-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030199513-A1 | Cinnoline derivatives and use as medicine | VEGFA, CNR1, CCR7 | FLT1 5/4885KDR 13/4885FGFR1 559/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.