Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.44 |
| ▸ | ATXN2 | Q99700 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6099116 | 1.00 | SMN1; SMN2 (0.46) | SMN1; SMN2CYP2C19OPRK1MEN1KMT2A | |
| SCHEMBL4979362 | 0.88 | MEN1 (0.46) | SMN1; SMN2CYP2C19OPRK1MEN1KMT2A | |
| SCHEMBL3728320 | 0.88 | XIAP (0.51) | SMN1; SMN2CYP2C19OPRK1MEN1KMT2A | |
| SCHEMBL4979370 | 0.88 | MEN1 (0.46) | SMN1; SMN2CYP2C19OPRK1MEN1KMT2A | |
| SCHEMBL15676882 | 0.88 | HDAC1 (0.46) | SMN1; SMN2CYP2C19OPRK1MEN1KMT2A | |
| SCHEMBL1196006 | 0.87 | MEN1 (0.51) | SMN1; SMN2CYP2C19OPRK1MEN1KMT2A | |
| SCHEMBL1196005 | 0.87 | MEN1 (0.51) | SMN1; SMN2CYP2C19OPRK1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL8582025 | 0.86 | MEN1 (0.50) | SMN1; SMN2CYP2C19OPRK1MEN1KMT2A | |
| SCHEMBL4884804 | 0.85 | GRIN2B (0.45) | SMN1; SMN2CYP2C19OPRK1MEN1KMT2A | |
| SCHEMBL6099124 | 0.84 | MEN1 (0.42) | SMN1; SMN2CYP2C19OPRK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060063791-A1 | (Spirocyclylamido)aminothiophene compounds | OSI PHARMACEUTICALS, INC. | 2006-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063791-A1 | (Spirocyclylamido)aminothiophene compounds | KIT, BRDT, MALT1 | SMN1; SMN2 1046/4885CYP2C19 1219/4885OPRK1 1722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.