Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 12/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.45 |
| ▸ | JAK3 | P52333 | 3/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.45 |
| ▸ | JAK1 | P23458 | 2/20 | 0.45 |
| ▸ | TYK2 | P29597 | 2/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | HCK | P08631 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
| ▸ | PRKCA | P17252 | 1/20 | 0.45 |
| ▸ | PRKACA | P17612 | 1/20 | 0.45 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3309370 | 0.96 | JAK2 (0.44) | JAK2CHEK1JAK3MAPK14JAK1 | |
| Trifluoroacetic Acid SCHEMBL2303931 | 0.88 | JAK2 (0.45) | JAK2CHEK1JAK3MAPK14JAK1 | |
| SCHEMBL3309375 | 0.88 | JAK2 (0.42) | JAK2CHEK1JAK3MAPK14JAK1 | |
| SCHEMBL3308960 | 0.88 | JAK2 (0.42) | JAK2CHEK1JAK3MAPK14JAK1 | |
| Trifluoroacetic Acid SCHEMBL2306449 | 0.86 | JAK2 (0.44) | JAK2CHEK1JAK3MAPK14JAK1 | |
| SCHEMBL15388875 | 0.82 | JAK2 (0.47) | JAK2CHEK1JAK3MAPK14JAK1 | |
| Trifluoroacetic Acid SCHEMBL3316202 | 0.82 | JAK2 (0.48) | JAK2CHEK1JAK3MAPK14JAK1 | |
| SCHEMBL2303934 | 0.81 | JAK2 (0.44) | JAK2CHEK1JAK3MAPK14JAK1 | |
| SCHEMBL2304190 | 0.80 | JAK2 (0.53) | JAK2CHEK1JAK3MAPK14JAK1 | |
| SCHEMBL2307006 | 0.80 | JAK2 (0.57) | JAK2CHEK1JAK3MAPK14JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060106020-A1 | Tetracyclic inhibitors of Janus kinases | INCYTE CORPORATION | 2006-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060106020-A1 | Tetracyclic inhibitors of Janus kinases | JAK1, JAK2, JAK3 | JAK2 2/4885CHEK1 412/4885JAK3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.