Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 13/20 | 0.45 |
| ▸ | AURKA | O14965 | 2/20 | 0.44 |
| ▸ | MET | P08581 | 2/20 | 0.44 |
| ▸ | TEK | Q02763 | 2/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | RET | P07949 | 2/20 | 0.42 |
| ▸ | LCK | P06239 | 2/20 | 0.42 |
| ▸ | KIF5B | P33176 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6031428 | 0.90 | KDR (0.53) | KDM1APDGFRBKDRAURKAMET | |
| SCHEMBL4380771 | 0.88 | KDM1A (0.51) | KDM1APDGFRBKDRAURKAMET | |
| SCHEMBL6099530 | 0.88 | KDR (0.48) | KDM1APDGFRBKDRAURKAMET | |
| SCHEMBL6101121 | 0.87 | KDM1A (0.53) | KDM1APDGFRBKDRAURKAMET | |
| SCHEMBL6030271 | 0.86 | KDM1A (0.51) | KDM1APDGFRBKDRAURKAMET | |
| SCHEMBL6098627 | 0.86 | KDR (0.45) | KDM1APDGFRBKDRMETTEK | |
| SCHEMBL6098956 | 0.85 | KDR (0.45) | KDM1APDGFRBKDRMETTEK | |
| SCHEMBL6031036 | 0.84 | KDM1A (0.56) | KDM1APDGFRBKDRAURKAMET | |
| SCHEMBL1401666 | 0.84 | KDM1A (0.54) | KDM1APDGFRBKDRAURKAMET | |
| SCHEMBL6029655 | 0.84 | KDM1A (0.52) | KDM1APDGFRBKDRAURKAMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492560-B2 | Quinazoline derivatives as angiogenesis inhibitors | ASTRAZENECA AB (SE) | 2013-07-23 | — | — | US | disclosed |
| US-7074800-B1 | Quinazoline derivatives as angiogenesis inhibitors | ASTRAZENECA AB (SE) | 2006-07-11 | — | — | US | disclosed |
| EP-1154774-A1 | QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | AstraZeneca AB (SE) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000047212-A1 | QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ASTRAZENECA AB (SE) | 2000-08-17 | — | — | WO | disclosed |