Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 11/20 | 0.56 |
| ▸ | STK4 | Q13043 | 1/20 | 0.49 |
| ▸ | STK3 | Q13188 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4858950 | 0.89 | EGFR (0.50) | EGFRERBB2JAK3BTK | |
| SCHEMBL5117292 | 0.88 | EGFR (0.53) | EGFRERBB2STK4STK3KCNH2 | |
| SCHEMBL4865132 | 0.86 | AURKA (0.52) | EGFRERBB2KCNH2AURKARPS6KB1 | |
| SCHEMBL4868107 | 0.86 | AURKA (0.51) | EGFRERBB2STK4STK3KCNH2 | |
| SCHEMBL4861054 | 0.85 | ERBB2 (0.54) | EGFRERBB2STK4STK3KCNH2 | |
| SCHEMBL2963863 | 0.85 | EGFR (0.53) | EGFRERBB2KCNH2JAK3BTK | |
| SCHEMBL2255343 | 0.84 | AURKA (0.54) | EGFRERBB2KCNH2AURKARPS6KB1 | |
| SCHEMBL4868089 | 0.84 | AURKA (0.52) | EGFRERBB2KCNH2AURKARPS6KB1 | |
| SCHEMBL5125233 | 0.83 | AURKA (0.51) | EGFRERBB2KCNH2AURKARPS6KB1 | |
| SCHEMBL4864883 | 0.82 | AURKA (0.57) | EGFRERBB2KCNH2AURKARPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006071079-A1 | QUINAZOLINE DERIVATIVES FOR INHIBITING CANCER CELL GROWTH AND METHOD FOR THE PREPARATION THEREOF | HANMI PHARM. CO., LTD. (KR) | 2006-07-06 | — | — | WO | claimed |
| WO-2006071079-A1 | QUINAZOLINE DERIVATIVES FOR INHIBITING CANCER CELL GROWTH AND METHOD FOR THE PREPARATION THEREOF | HANMI PHARM. CO., LTD. (KR) | 2006-07-06 | — | — | WO | disclosed |