Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.70 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.70 |
| ▸ | KDR | P35968 | 4/20 | 0.61 |
| ▸ | SRC | P12931 | 3/20 | 0.61 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.61 |
| ▸ | CIT | O14578 | 1/20 | 0.61 |
| ▸ | GAK | O14976 | 1/20 | 0.61 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.61 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.61 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.61 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.61 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.61 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.61 |
| ▸ | STK17B | O94768 | 1/20 | 0.61 |
| ▸ | STK10 | O94804 | 1/20 | 0.61 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.61 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.61 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.61 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.61 |
| ▸ | ABL1 | P00519 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21835284 | 0.96 | EGFR (0.69) | EGFRERBB2KDRSRCEPHB4 | |
| SCHEMBL23406671 | 0.92 | EGFR (0.68) | EGFRERBB2KDRSRCEPHB4 | |
| SCHEMBL29944978 | 0.92 | EGFR (0.68) | EGFRERBB2KDRSRCEPHB4 | |
| SCHEMBL29944974 | 0.92 | EGFR (0.64) | EGFRERBB2KDRSRCEPHB4 | |
| SCHEMBL29944990 | 0.92 | EGFR (0.64) | EGFRERBB2KDRSRCEPHB4 | |
| SCHEMBL21835221 | 0.90 | EGFR (0.62) | EGFRERBB2KDRSRCEPHB4 | |
| SCHEMBL4858957 | 0.87 | EGFR (0.70) | EGFRERBB2KDRSRCEPHB4 | |
| SCHEMBL21835303 | 0.86 | EGFR (0.70) | EGFRERBB2LCKERBB3KCNH2 | |
| SCHEMBL23406765 | 0.86 | EGFR (0.55) | EGFRERBB2KDREPHB4LCK | |
| SCHEMBL29944988 | 0.86 | EGFR (0.55) | EGFRERBB2KDREPHB4LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006071079-A1 | QUINAZOLINE DERIVATIVES FOR INHIBITING CANCER CELL GROWTH AND METHOD FOR THE PREPARATION THEREOF | HANMI PHARM. CO., LTD. (KR) | 2006-07-06 | — | — | WO | claimed |
| WO-2006071079-A1 | QUINAZOLINE DERIVATIVES FOR INHIBITING CANCER CELL GROWTH AND METHOD FOR THE PREPARATION THEREOF | HANMI PHARM. CO., LTD. (KR) | 2006-07-06 | — | — | WO | disclosed |