Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.54 |
| ▸ | PRKAA1 | Q13131 | 13/20 | 0.52 |
| ▸ | PRKAA2 | P54646 | 11/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.52 |
| ▸ | EGFR | P00533 | 4/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 3/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.43 |
| ▸ | PLK4 | O00444 | 2/20 | 0.43 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.43 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.43 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.43 |
| ▸ | INSR | P06213 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6101970 | 1.00 | KDR (0.54) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| SCHEMBL6090821 | 0.88 | KDR (0.55) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| SCHEMBL6090825 | 0.88 | KDR (0.55) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| SCHEMBL6090725 | 0.85 | KDR (0.53) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| SCHEMBL6090716 | 0.85 | KDR (0.53) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| SCHEMBL6087845 | 0.84 | PDGFRB (0.43) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| SCHEMBL6087837 | 0.84 | PDGFRB (0.43) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| SCHEMBL6099515 | 0.84 | PDGFRB (0.43) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| SCHEMBL6088002 | 0.81 | ALK (0.43) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| SCHEMBL6092769 | 0.81 | CHEK1 (0.40) | KDRPRKAA1PRKAA2PDGFRBFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218373-A2 | 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-03 | — | — | EP | claimed |
| WO-2001009121-A2 | 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-08 | — | — | WO | claimed |
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |
| EP-1218373-A2 | 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001009121-A2 | 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-08 | — | — | WO | disclosed |