Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | STK4 | Q13043 | 1/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 14/20 | 0.45 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.45 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.45 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4868534 | 0.94 | KDR (0.49) | EGFRKDRSTK4ERBB2FLT1 | |
| SCHEMBL6103472 | 0.89 | EGFR (0.48) | EGFRKDRERBB2FLT1EPHA2 | |
| SCHEMBL5125813 | 0.87 | EGFR (0.42) | EGFRKDRSTK4ERBB2FLT1 | |
| SCHEMBL4861054 | 0.87 | ERBB2 (0.54) | EGFRSTK4ERBB2ERBB4AURKA | |
| SCHEMBL4867050 | 0.85 | EGFR (0.47) | EGFRKDRSTK4ERBB2FLT1 | |
| SCHEMBL4858950 | 0.85 | EGFR (0.50) | EGFRERBB2 | |
| SCHEMBL2255343 | 0.82 | AURKA (0.54) | EGFRERBB2ERBB4AURKARPS6KB1 | |
| SCHEMBL4865094 | 0.81 | EGFR (0.56) | EGFRERBB2ERBB4 | |
| SCHEMBL26636 | 0.81 | EGFR (0.47) | EGFRERBB2ERBB4AURKARPS6KB1 | |
| SCHEMBL4868107 | 0.80 | AURKA (0.51) | EGFRSTK4ERBB2ERBB4AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006071079-A1 | QUINAZOLINE DERIVATIVES FOR INHIBITING CANCER CELL GROWTH AND METHOD FOR THE PREPARATION THEREOF | HANMI PHARM. CO., LTD. (KR) | 2006-07-06 | — | — | WO | claimed |
| WO-2006071079-A1 | QUINAZOLINE DERIVATIVES FOR INHIBITING CANCER CELL GROWTH AND METHOD FOR THE PREPARATION THEREOF | HANMI PHARM. CO., LTD. (KR) | 2006-07-06 | — | — | WO | disclosed |