Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 12/20 | 0.47 |
| ▸ | KIT | P10721 | 10/20 | 0.47 |
| ▸ | FLT3 | P36888 | 4/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.42 |
| ▸ | SRC | P12931 | 3/20 | 0.39 |
| ▸ | LCK | P06239 | 2/20 | 0.38 |
| ▸ | FYN | P06241 | 2/20 | 0.38 |
| ▸ | YES1 | P07947 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | TLK2 | Q86UE8 | 2/20 | 0.37 |
| ▸ | RIOK2 | Q9BVS4 | 2/20 | 0.37 |
| ▸ | TLK1 | Q9UKI8 | 2/20 | 0.37 |
| ▸ | FLT1 | P17948 | 2/20 | 0.37 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | STK25 | O00506 | 1/20 | 0.37 |
| ▸ | CIT | O14578 | 1/20 | 0.37 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6103228 | 1.00 | KDR (0.47) | KDRPDGFRBKITFLT3LRRK2 | |
| SCHEMBL6103566 | 0.93 | PDGFRB (0.41) | KDRPDGFRBKITFLT3LRRK2 | |
| SCHEMBL6103573 | 0.93 | PDGFRB (0.41) | KDRPDGFRBKITFLT3LRRK2 | |
| SCHEMBL6102322 | 0.89 | PDGFRB (0.40) | KDRPDGFRBKITFLT3FGFR1 | |
| SCHEMBL6102326 | 0.89 | PDGFRB (0.40) | KDRPDGFRBKITFLT3FGFR1 | |
| SCHEMBL6101503 | 0.84 | PDGFRB (0.39) | KDRPDGFRBKITFLT3LRRK2 | |
| SCHEMBL6101501 | 0.84 | PDGFRB (0.39) | KDRPDGFRBKITFLT3LRRK2 | |
| SCHEMBL6103094 | 0.83 | PDGFRB (0.47) | KDRPDGFRBKITFLT3LRRK2 | |
| SCHEMBL6103091 | 0.83 | PDGFRB (0.47) | KDRPDGFRBKITFLT3LRRK2 | |
| SCHEMBL4309393 | 0.83 | PDGFRB (0.38) | KDRPDGFRBKITFLT3LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060004084-A1 | (3Z)-3-(2,3-dihydro-1H-inden-1-ylidene)-1,3-dihydro-2H-indol-2-ones as kinase inhibitors | ALLERGAN, INC. | 2006-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060004084-A1 | (3Z)-3-(2,3-dihydro-1H-inden-1-ylidene)-1,3-dihydro-2H-indol-2-ones as kinase inhibitors | CDK2, ERBB2, MAP3K3 | KDR 320/4885PDGFRB 502/4885KIT 683/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.