Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 16/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 13/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL611306 | 0.78 | CHRNA7 (0.62) | CHRNA7KCNH2 | |
| SCHEMBL21246740 | 0.77 | CHRNA7 (0.50) | CHRNA7KCNH2 | |
| SCHEMBL9141665 | 0.76 | CHRNA7 (0.55) | CHRNA7KCNH2 | |
| SCHEMBL9141651 | 0.76 | CHRNA7 (0.55) | CHRNA7KCNH2 | |
| SCHEMBL9141657 | 0.76 | CHRNA7 (0.55) | CHRNA7KCNH2 | |
| SCHEMBL9142830 | 0.76 | CHRNA7 (0.55) | CHRNA7KCNH2 | |
| SCHEMBL9142821 | 0.76 | CHRNA7 (0.55) | CHRNA7KCNH2 | |
| SCHEMBL15743901 | 0.75 | CHRNA7 (0.66) | CHRNA7KCNH2 | |
| SCHEMBL25557071 | 0.75 | CHRNA7 (0.50) | CHRNA7KCNH2 | |
| SCHEMBL21262667 | 0.74 | CHRNA7 (0.64) | CHRNA7KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8940741-B2 | Inhibitors of bruton's tyrosine kinase | HOFFMANN-LA ROCHE INC. (US) | 2015-01-27 | — | — | US | disclosed |
| EP-2603500-B1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | HOFFMANN LA ROCHE (CH) | 2014-11-19 | — | — | EP | disclosed |
| US-20130178461-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | HOFFMANN-LA ROCHE INC. (US) | 2013-07-11 | — | — | US | disclosed |
| US-8481540-B2 | Inhibitors of bruton's tyrosine kinase | HOFFMANN-LA ROCHE INC. (US) | 2013-07-09 | — | — | US | disclosed |
| US-20120040949-A1 | Inhibitors of Bruton's Tyrosine Kinase | BERTHEL STEVEN JOSEPH (US) | 2012-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040949-A1 | Inhibitors of Bruton's Tyrosine Kinase | BTK, SYK, LYN | CHRNA7 3929/4885KCNH2 2941/4885 |
| US-20130178461-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | BTK, SYK, LYN | CHRNA7 3929/4885KCNH2 2941/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.