Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNFRSF1A | P19438 | 15/20 | 0.50 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6109489 | 0.90 | TNFRSF1A (0.50) | TNFRSF1AMEN1ALDH1A1TP53CYP3A4 | |
| SCHEMBL6110383 | 0.83 | TNFRSF1A (0.58) | TNFRSF1AABCG2MEN1ALDH1A1TP53 | |
| SCHEMBL25208831 | 0.83 | TNFRSF1A (0.58) | TNFRSF1AABCG2MEN1ALDH1A1TP53 | |
| SCHEMBL6093024 | 0.80 | PPARG (0.42) | TNFRSF1AMAPTKDM4E | |
| SCHEMBL6091213 | 0.79 | TNFRSF1A (0.42) | TNFRSF1AMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL6109512 | 0.78 | TNFRSF1A (0.58) | TNFRSF1AABCG2MEN1ALDH1A1TP53 | |
| SCHEMBL6111525 | 0.75 | TNFRSF1A (0.81) | TNFRSF1A | |
| SCHEMBL6093002 | 0.75 | PPARA (0.42) | TNFRSF1AMAPTKDM4EMAPK1 | |
| SCHEMBL6091494 | 0.74 | TNFRSF1A (0.44) | TNFRSF1AMEN1ALDH1A1CYP3A4MAPT | |
| SCHEMBL6111017 | 0.70 | TNFRSF1A (0.49) | TNFRSF1AMEN1ALDH1A1TP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006004903-A2 | 1,2-BIS-(SUBSTITUTED-PHENYL)-2-PROPEN-1-ONES AND PHARMACEUTICAL COMPOSITIONS THEREOF | ATHEROGENICS, INC. (US) | 2006-01-12 | — | — | WO | claimed |
| WO-2006004903-A2 | 1,2-BIS-(SUBSTITUTED-PHENYL)-2-PROPEN-1-ONES AND PHARMACEUTICAL COMPOSITIONS THEREOF | ATHEROGENICS, INC. (US) | 2006-01-12 | — | — | WO | disclosed |