Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNFRSF1A | P19438 | 14/20 | 0.44 |
| ▸ | KDR | P35968 | 3/20 | 0.40 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.38 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6110903 | 0.93 | TNFRSF1A (0.47) | TNFRSF1ASRPK1RPS6KB2 | |
| SCHEMBL6110611 | 0.81 | TNFRSF1A (0.67) | TNFRSF1A | |
| SCHEMBL6090580 | 0.77 | POLB (0.38) | SRPK1RPS6KB2 | |
| SCHEMBL6091074 | 0.76 | AR (0.38) | TNFRSF1ASRPK1RPS6KB2 | |
| SCHEMBL6040883 | 0.72 | TNFRSF1A (0.61) | TNFRSF1A | |
| SCHEMBL6040888 | 0.72 | TNFRSF1A (0.61) | TNFRSF1A | |
| SCHEMBL27142785 | 0.72 | SRPK1 (0.50) | SRPK1RPS6KB2 | |
| SCHEMBL6092865 | 0.70 | AR (0.40) | SRPK1RPS6KB2 | |
| SCHEMBL6092305 | 0.70 | AR (0.42) | TNFRSF1ASRPK1RPS6KB2 | |
| SCHEMBL30258436 | 0.67 | SRPK1 (0.50) | TNFRSF1ASRPK1RPS6KB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006004903-A2 | 1,2-BIS-(SUBSTITUTED-PHENYL)-2-PROPEN-1-ONES AND PHARMACEUTICAL COMPOSITIONS THEREOF | ATHEROGENICS, INC. (US) | 2006-01-12 | — | — | WO | claimed |
| WO-2006004903-A2 | 1,2-BIS-(SUBSTITUTED-PHENYL)-2-PROPEN-1-ONES AND PHARMACEUTICAL COMPOSITIONS THEREOF | ATHEROGENICS, INC. (US) | 2006-01-12 | — | — | WO | disclosed |