Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNFRSF1A | P19438 | 13/20 | 0.45 |
| ▸ | ERN1 | O75460 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6111741 | 0.90 | ERN1 (0.42) | TNFRSF1AERN1KDM4EALDH1A1MEN1 | |
| SCHEMBL6109931 | 0.89 | ERN1 (0.48) | TNFRSF1AERN1KDM4EALDH1A1MEN1 | |
| SCHEMBL6111644 | 0.89 | TNFRSF1A (0.44) | TNFRSF1AERN1KDM4EALDH1A1MEN1 | |
| SCHEMBL6110988 | 0.88 | ERN1 (0.42) | TNFRSF1AERN1KDM4EMAPTALDH1A1 | |
| SCHEMBL6110186 | 0.85 | ABCB1 (0.42) | TNFRSF1AERN1MAPTALDH1A1MEN1 | |
| SCHEMBL6109564 | 0.85 | TNFRSF1A (0.50) | TNFRSF1AERN1KDM4EMAPTALDH1A1 | |
| SCHEMBL6110257 | 0.83 | HIF1A (0.41) | TNFRSF1AERN1ALDH1A1 | |
| SCHEMBL6110052 | 0.81 | TNFRSF1A (0.39) | TNFRSF1AERN1KDM4EALDH1A1MEN1 | |
| SCHEMBL6110101 | 0.81 | TNFRSF1A (0.46) | TNFRSF1AERN1KDM4EMAPTALDH1A1 | |
| SCHEMBL6110336 | 0.80 | TNFRSF1A (0.43) | TNFRSF1AERN1KDM4EMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006004903-A2 | 1,2-BIS-(SUBSTITUTED-PHENYL)-2-PROPEN-1-ONES AND PHARMACEUTICAL COMPOSITIONS THEREOF | ATHEROGENICS, INC. (US) | 2006-01-12 | — | — | WO | disclosed |