Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 9/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | LIMK1 | P53667 | 4/20 | 0.52 |
| ▸ | CHUK | O15111 | 1/20 | 0.52 |
| ▸ | PRKACA | P17612 | 1/20 | 0.52 |
| ▸ | PRKACG | P22612 | 1/20 | 0.52 |
| ▸ | PRKACB | P22694 | 1/20 | 0.52 |
| ▸ | BTK | Q06187 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6109707 | 0.90 | MAPT (0.56) | IKBKBHPGDMAPTKMT2AMEN1 | |
| SCHEMBL6110090 | 0.90 | IKBKB (0.65) | IKBKBHPGDMAPTKMT2AMEN1 | |
| SCHEMBL6110291 | 0.90 | KMT2A (0.71) | IKBKBMAPTKMT2AMEN1HTT | |
| SCHEMBL5805575 | 0.89 | MAPT (0.61) | IKBKBMAPTKMT2AMEN1LIMK1 | |
| SCHEMBL6110367 | 0.88 | MAPT (0.54) | IKBKBHPGDMAPTKMT2AMEN1 | |
| SCHEMBL6111076 | 0.87 | IKBKB (0.56) | IKBKBHPGDMAPTKMT2AMEN1 | |
| SCHEMBL6110902 | 0.87 | KMT2A (0.55) | IKBKBHPGDMAPTKMT2AMEN1 | |
| SCHEMBL6110686 | 0.87 | IKBKB (0.67) | IKBKBHPGDMAPTKMT2AMEN1 | |
| SCHEMBL6110019 | 0.86 | MAPT (0.52) | IKBKBHPGDMAPTKMT2AMEN1 | |
| SCHEMBL6110791 | 0.86 | IKBKB (0.55) | IKBKBHPGDMAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006010568-A2 | SUBSTITUTED PYRIDO[3',2':4,5]THIENO[3,2-D]PYRIMIDINE-2,4(1 H,3H)-DIONES AND -4(3H)-ONES, PYRIDO[3',2':4,5]FURO[3,2-D]PYRIMIDINE-2,4(1 H,3H)-DIONES AND -4(3H)-ONES, AND USE THEREOF AS INHIBITORS OF TNF-ALPHA RELEASE | CURACYTE DISCOVERY GMBH (DE) | 2006-02-02 | — | — | WO | disclosed |