Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.52 |
| ▸ | BRD4 | O60885 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.41 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.41 |
| ▸ | ANO2 | Q9NQ90 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 2/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6118858 | 0.93 | MAPK14 (0.52) | MAPK14BRD4TSHRKDM4EALDH1A1 | |
| SCHEMBL6119004 | 0.89 | MAPK14 (0.55) | MAPK14TSHRLMNASCN5AANO1 | |
| SCHEMBL6118279 | 0.88 | MAPK14 (0.57) | MAPK14TSHRKDM4EALDH1A1HSD17B10 | |
| SCHEMBL6118528 | 0.84 | MAPK14 (0.57) | MAPK14TSHRKDM4EALDH1A1HSD17B10 | |
| SCHEMBL6118060 | 0.82 | MAPK14 (0.58) | MAPK14BRD4TSHRKDM4EALDH1A1 | |
| SCHEMBL6118440 | 0.81 | MAPK14 (0.57) | MAPK14TSHRKDM4EALDH1A1HSD17B10 | |
| SCHEMBL6118911 | 0.81 | MAPK14 (0.61) | MAPK14TSHRKDM4EALDH1A1HSD17B10 | |
| SCHEMBL6118978 | 0.81 | MAPK14 (0.54) | MAPK14TSHRKDM4EALDH1A1HSD17B10 | |
| SCHEMBL6118405 | 0.80 | MAPK14 (0.56) | MAPK14TSHRKDM4EALDH1A1HSD17B10 | |
| SCHEMBL6118608 | 0.79 | MAPK14 (0.55) | MAPK14TSHRKDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012065546-A1 | 3-ARYL-6-ARYL-[1,2,4]TRIAZOLO[4,3-a]PYRIDINES AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF | IMPACT THERAPEUTICS, INC. (CN) | 2012-05-24 | — | — | WO | claimed |
| WO-2012065297-A1 | 3-ARYL-6-ARYL-[1,2,4]TRIAZOLO[4,3-a]PYRIDINES AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF | IMPACT THERAPEUTICS, INC. (CN) | 2012-05-24 | — | — | WO | claimed |
| US-9199983-B2 | 3-aryl-6-aryl-[1,2,4]triazolo[4,3-α]pyridines as inhibitors of cell proliferation and the use thereof | CAI SUIXIONG (CN) | 2015-12-01 | — | — | US | disclosed |
| WO-2012065546-A1 | 3-ARYL-6-ARYL-[1,2,4]TRIAZOLO[4,3-a]PYRIDINES AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF | IMPACT THERAPEUTICS, INC. (CN) | 2012-05-24 | — | — | WO | disclosed |
| WO-2012065297-A1 | 3-ARYL-6-ARYL-[1,2,4]TRIAZOLO[4,3-a]PYRIDINES AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF | IMPACT THERAPEUTICS, INC. (CN) | 2012-05-24 | — | — | WO | disclosed |