Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | CFTR | P13569 | 4/20 | 0.43 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.36 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6119249 | 0.82 | SOS1 (0.40) | KDM4EPOLBCFTRMBOAT4GAA | |
| SCHEMBL6118855 | 0.80 | KDM4E (0.55) | KDM4EPOLBCFTRGAAALDH1A1 | |
| SCHEMBL22954314 | 0.79 | CFTR (0.41) | KDM4EPOLBCFTRGAAALDH1A1 | |
| SCHEMBL22954127 | 0.78 | MAPT (0.47) | KDM4ECFTRGAAALDH1A1HSD17B10 | |
| SCHEMBL6119213 | 0.78 | CFTR (0.54) | KDM4EPOLBCFTRMBOAT4GAA | |
| SCHEMBL6118859 | 0.77 | KDM4E (0.49) | KDM4EPOLBCFTRGAAALDH1A1 | |
| SCHEMBL16929776 | 0.77 | CFTR (0.44) | KDM4EPOLBCFTRGAAALDH1A1 | |
| SCHEMBL3534227 | 0.77 | KCNK3 (0.49) | KDM4EPOLBCFTRGAAALDH1A1 | |
| SCHEMBL3530294 | 0.76 | KDM4E (0.57) | KDM4EPOLBCFTRMBOAT4GAA | |
| SCHEMBL24616520 | 0.75 | KDM4E (0.46) | KDM4EPOLBCFTRMBOAT4GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012067663-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-05-24 | — | — | WO | disclosed |