Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.36 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL856412 | 0.74 | HSD17B10 (0.54) | HSD17B10KDM4EGAANPC1MEN1 | |
| SCHEMBL862274 | 0.67 | HSD17B10 (0.52) | HSD17B10KDM4EGAANPC1MEN1 | |
| SCHEMBL6118943 | 0.67 | HSD17B10 (0.66) | HSD17B10KDM4EGAANPC1MEN1 | |
| SCHEMBL856697 | 0.66 | HSD17B10 (0.50) | HSD17B10KDM4EGAANPC1MEN1 | |
| SCHEMBL6120283 | 0.65 | — | — | |
| SCHEMBL6125985 | 0.63 | NPC1 (0.39) | HSD17B10KDM4EGAANPC1MEN1 | |
| SCHEMBL6119304 | 0.63 | HSD17B10 (0.71) | HSD17B10KDM4EGAANPC1MEN1 | |
| SCHEMBL6119699 | 0.63 | HSD17B10 (0.48) | HSD17B10KDM4EGAANPC1MEN1 | |
| SCHEMBL6119695 | 0.63 | HSD17B10 (0.48) | HSD17B10KDM4EGAANPC1MEN1 | |
| SCHEMBL858207 | 0.63 | HSD17B10 (0.57) | HSD17B10KDM4EGAANPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2640366-A2 | BENZOXAZEPINES AS INHIBITORS OF PI3K/MTOR AND METHODS OF THEIR USE AND MANUFACTURE | Exelixis, Inc. (US) | 2013-09-25 | — | — | EP | disclosed |
| WO-2012068096-A2 | BENZOXAZEPINES AS INHIBITORS OF PI3K/MTOR AND METHODS OF THEIR USE AND MANUFACTURE | EXELIXIS, INC. (US) | 2012-05-24 | — | — | WO | disclosed |