⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6242950 | 0.75 | ANPEP (0.40) | — | |
| SCHEMBL23683384 | 0.74 | — | — | |
| SCHEMBL11502810 | 0.73 | TSHR (0.33) | — | |
| SCHEMBL6373695 | 0.72 | — | — | |
| SCHEMBL10645883 | 0.70 | — | — | |
| SCHEMBL3734197 | 0.70 | — | — | |
| SCHEMBL11260080 | 0.69 | — | — | |
| SCHEMBL2430437 | 0.68 | — | — | |
| SCHEMBL27209690 | 0.68 | — | — | |
| SCHEMBL873184 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117466958-A | Large-scale preparation of pseudotrisaccharide aminoglycosides and intermediates thereof | ELOXX制药有限公司 | 2024-01-30 | — | — | CN | disclosed |
| US-11865128-B2 | Aminoglycosides and uses thereof in treating genetic disorders | TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) | 2024-01-09 | — | — | US | disclosed |
| CN-110997689-B | Aminoglycoside derivatives and their use in the treatment of genetic disorders | ELOXX制药有限公司 | 2023-11-07 | — | — | CN | disclosed |
| CN-110637024-B | Large-scale preparation of pseudotrisaccharide aminoglycosides and intermediates thereof | ELOXX制药有限公司 | 2023-10-24 | — | — | CN | disclosed |
| US-11786539-B2 | Aminoglycoside derivatives and uses thereof in treating genetic disorders | ELOXX PHARMACEUTICALS LTD. (IL) | 2023-10-17 | — | — | US | disclosed |
| US-20230097398-A1 | AMINOGLYCOSIDE DERIVATIVES AND USES THEREOF IN TREATING GENETIC DISORDERS | ELOXX PHARMACEUTICALS LTD. (IL) | 2023-03-30 | — | — | US | disclosed |
| US-11613551-B2 | Aminoglycoside derivatives and uses thereof in treating genetic disorders | ELOXX PHARMACEUTICALS LTD. (IL) | 2023-03-28 | — | — | US | disclosed |
| CN-114957357-A | Aminoglycoside derivatives and their use in the treatment of genetic disorders | ELOXX制药有限公司 | 2022-08-30 | — | — | CN | disclosed |
| CN-108350014-B | Aminoglycoside derivatives and their use in the treatment of genetic disorders | ELOXX制药有限公司 | 2022-06-10 | — | — | CN | disclosed |
| US-11306115-B2 | Aminoglycoside derivatives and uses thereof in treating genetic disorders | ELOXX PHARMACEUTICALS LTD. (IL) | 2022-04-19 | — | — | US | disclosed |
| WO-2017037718-A1 | AMINOGLYCOSIDE DERIVATIVES AND USES THEREOF IN TREATING GENETIC DISORDERS | ELOXX PHARMACEUTICALS LTD. (IL) | 2017-03-09 | — | — | WO | disclosed |
| WO-2017037719-A1 | AMINOGLYCOSIDE DERIVATIVES AND USES THEREOF IN TREATING GENETIC DISORDERS | ELOXX PHARMACEUTICALS LTD. (IL) | 2017-03-09 | — | — | WO | disclosed |
| US-20160074425-A1 | AMINOGLYCOSIDES AND USES THEREOF IN TREATING GENETIC DISORDERS | TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) | 2016-03-17 | — | — | US | disclosed |
| WO-2015186134-A1 | USE OF AMINOGLYCOSIDE ANALOGS IN THE TREATMENT OF RETT SYNDROME | ELOXX PHARMACEUTICALS LTD. (IL) | 2015-12-10 | — | — | WO | disclosed |
| US-9175029-B2 | Aminoglycosides and uses thereof in treating genetic disorders | TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) | 2015-11-03 | — | — | US | disclosed |
| US-20140357590-A1 | AMINOGLYCOSIDES AND USES THEREOF IN TREATING GENETIC DISORDERS | TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) | 2014-12-04 | — | — | US | disclosed |
| US-8895519-B2 | Aminoglycosides and uses thereof in treating genetic disorders | TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) | 2014-11-25 | — | — | US | disclosed |
| EP-2640734-A1 | AMINOGLYCOSIDES AND USES THEREOF IN TREATING GENETIC DISORDERS | Technion Research & Development Foundation Ltd. (IL) | 2013-09-25 | — | — | EP | disclosed |
| US-20130237489-A1 | AMINOGLYCOSIDES AND USES THEREOF IN TREATING GENETIC DISORDERS | TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) | 2013-09-12 | — | — | US | disclosed |
| WO-2012066546-A1 | AMINOGLYCOSIDES AND USES THEREOF IN TREATING GENETIC DISORDERS | TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD. (IL) | 2012-05-24 | — | — | WO | disclosed |