Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 14/20 | 0.56 |
| ▸ | MMEL1 | Q495T6 | 5/20 | 0.56 |
| ▸ | ACE | P12821 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2707455 | 1.00 | MME (0.56) | MMEMMEL1ACE | |
| SCHEMBL2707412 | 0.90 | MME (0.54) | MMEMMEL1ACE | |
| SCHEMBL18672735 | 0.90 | MME (0.54) | MMEMMEL1ACE | |
| SCHEMBL18672691 | 0.89 | MME (0.70) | MMEMMEL1ACE | |
| SCHEMBL2705953 | 0.89 | MME (0.70) | MMEMMEL1ACE | |
| SCHEMBL12317398 | 0.85 | MME (0.50) | MMEMMEL1ACE | |
| SCHEMBL18672729 | 0.85 | MME (0.50) | MMEMMEL1ACE | |
| SCHEMBL2705976 | 0.84 | MME (0.79) | MMEMMEL1ACE | |
| SCHEMBL18672713 | 0.83 | MME (0.56) | MMEMMEL1ACE | |
| SCHEMBL12317396 | 0.83 | MME (0.56) | MMEMMEL1ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2640375-A1 | METHOD OF TREATING CONTRAST-INDUCED NEPHROPATHY | Novartis AG (CH) | 2013-09-25 | — | — | EP | disclosed |
| WO-2012065958-A1 | METHOD OF TREATING CONTRAST-INDUCED NEPHROPATHY | NOVARTIS AG (CH) | 2012-05-24 | — | — | WO | disclosed |