Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 6/20 | 0.46 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6124156 | 0.90 | KDM1A (0.44) | KDM1ASRD5A1CYP17A1CYP3A4CYP11B2 | |
| SCHEMBL24538626 | 0.75 | KDM1A (0.44) | KDM1ASRD5A1CYP17A1CYP3A4CYP11B2 | |
| Hydrochloric Acid SCHEMBL9715536 | 0.71 | KDM1A (0.41) | KDM1ASRD5A1CYP17A1CYP3A4CYP11B2 | |
| SCHEMBL17931722 | 0.71 | KDM1A (0.41) | KDM1ASRD5A1CYP17A1CYP3A4CYP11B2 | |
| SCHEMBL20738977 | 0.71 | KDM1A (0.41) | KDM1ASRD5A1CYP17A1CYP3A4CYP11B2 | |
| SCHEMBL16501543 | 0.69 | SRD5A1 (0.46) | KDM1ASRD5A1CYP17A1CYP3A4CYP11B2 | |
| SCHEMBL12234883 | 0.69 | AKR1B1 (0.41) | — | |
| SCHEMBL19126994 | 0.68 | KDM1A (0.36) | KDM1ASRD5A1CYP17A1CYP3A4CYP11B2 | |
| SCHEMBL12188662 | 0.68 | KDM1A (0.56) | KDM1ASRD5A1CYP17A1CYP3A4CYP11B2 | |
| SCHEMBL27305458 | 0.68 | HTR1D (0.43) | KDM1ASRD5A1HTR2AHTR2CACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8487099-B2 | Gamma secretase modulators | MERCK SHARP & DOHME CORP. (US) | 2013-07-16 | — | — | US | disclosed |
| US-20120107328-A1 | GAMMA SECRETASE MODULATORS | MERCK SHARP & DOHME CORP. | 2012-05-03 | — | — | US | disclosed |
| US-20110263529-A1 | GAMMA SECRETASE MODULATORS | MERCK SHARP & DOHME CORP. | 2011-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120107328-A1 | GAMMA SECRETASE MODULATORS | BACE1, BACE2, PSEN1 | KDM1A 3235/4885SRD5A1 2162/4885CYP17A1 624/4885 |
| US-20110263529-A1 | GAMMA SECRETASE MODULATORS | BACE1, BACE2, PSEN1 | KDM1A 2758/4885SRD5A1 3715/4885CYP17A1 2596/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.