Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 18/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6127799 | 0.82 | CREBBP (0.40) | IDO1KCNH2CYP2C9CYP3A4CREBBP | |
| SCHEMBL22158281 | 0.76 | IDO1 (0.43) | IDO1KCNH2CYP2C9CYP3A4 | |
| SCHEMBL6124236 | 0.76 | NOTUM (0.44) | IDO1KCNH2CYP2C9CYP3A4 | |
| SCHEMBL22397636 | 0.75 | IDO1 (0.47) | IDO1KCNH2CYP2C9CYP3A4 | |
| SCHEMBL6124247 | 0.73 | IDO1 (0.43) | IDO1KCNH2CYP2C9CYP3A4 | |
| SCHEMBL23494325 | 0.71 | IDO1 (0.54) | IDO1KCNH2CYP2C9CYP3A4 | |
| SCHEMBL23494327 | 0.71 | IDO1 (0.54) | IDO1KCNH2CYP2C9CYP3A4 | |
| SCHEMBL31492891 | 0.71 | IDO1 (0.54) | IDO1KCNH2CYP2C9CYP3A4 | |
| SCHEMBL22397510 | 0.69 | IDO1 (0.60) | IDO1KCNH2CYP2C9CYP3A4 | |
| SCHEMBL22397599 | 0.69 | IDO1 (0.55) | IDO1KCNH2CYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8809318-B2 | Gamma secretase modulators | MERCK SHARP & DOHME CORP. (US) | 2014-08-19 | — | — | US | disclosed |
| US-8487099-B2 | Gamma secretase modulators | MERCK SHARP & DOHME CORP. (US) | 2013-07-16 | — | — | US | disclosed |
| US-20120129846-A1 | GAMMA SECRETASE MODULATORS | Merck, Sharp & Dohme, Corp. | 2012-05-24 | — | — | US | disclosed |
| US-20120107328-A1 | GAMMA SECRETASE MODULATORS | MERCK SHARP & DOHME CORP. | 2012-05-03 | — | — | US | disclosed |
| US-20110306593-A1 | GAMMA SECRETASE MODULATORS | MERCK SHARP & DOHME LLC | 2011-12-15 | — | — | US | disclosed |
| US-20110263529-A1 | GAMMA SECRETASE MODULATORS | MERCK SHARP & DOHME CORP. | 2011-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120107328-A1 | GAMMA SECRETASE MODULATORS | BACE1, BACE2, PSEN1 | IDO1 4504/4885KCNH2 4241/4885CYP2C9 4486/4885 |
| US-20120129846-A1 | GAMMA SECRETASE MODULATORS | BACE1, BACE2, PSEN1 | IDO1 4402/4885KCNH2 4062/4885CYP2C9 4388/4885 |
| US-20110306593-A1 | GAMMA SECRETASE MODULATORS | BACE1, BACE2, PSEN1 | IDO1 3823/4885KCNH2 4131/4885CYP2C9 3849/4885 |
| US-20110263529-A1 | GAMMA SECRETASE MODULATORS | BACE1, BACE2, PSEN1 | IDO1 4405/4885KCNH2 4023/4885CYP2C9 4650/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.