Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | RORC | P51449 | 3/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.44 |
| ▸ | ATXN2 | Q99700 | 1/20 | 0.44 |
| ▸ | ACACB | O00763 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6124701 | 0.93 | SMN1; SMN2 (0.47) | SMN1; SMN2MEN1KMT2ANPSR1CYP2C19 | |
| SCHEMBL6124700 | 0.93 | MEN1 (0.54) | SMN1; SMN2MEN1KMT2ANPSR1CYP2C19 | |
| SCHEMBL19622344 | 0.87 | MEN1 (0.59) | SMN1; SMN2MEN1KMT2ANPSR1CYP2C19 | |
| SCHEMBL19622333 | 0.84 | MEN1 (0.55) | SMN1; SMN2MEN1KMT2ANPSR1CYP2C19 | |
| SCHEMBL6127870 | 0.84 | MEN1 (0.56) | SMN1; SMN2MEN1KMT2ANPSR1CYP2C19 | |
| SCHEMBL6127863 | 0.82 | NPC1 (0.51) | SMN1; SMN2MEN1KMT2ANPSR1CYP2C19 | |
| SCHEMBL3273418 | 0.81 | MEN1 (0.52) | SMN1; SMN2MEN1KMT2ANPSR1CYP2C19 | |
| SCHEMBL19779322 | 0.81 | MEN1 (0.52) | SMN1; SMN2MEN1KMT2ANPSR1CYP2C19 | |
| SCHEMBL15504877 | 0.80 | MEN1 (0.57) | SMN1; SMN2MEN1KMT2ANPSR1CYP2C19 | |
| SCHEMBL34473717 | 0.80 | KDM1A (0.55) | SMN1; SMN2MEN1KMT2ANPSR1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8487099-B2 | Gamma secretase modulators | MERCK SHARP & DOHME CORP. (US) | 2013-07-16 | — | — | US | disclosed |
| US-20120107328-A1 | GAMMA SECRETASE MODULATORS | MERCK SHARP & DOHME CORP. | 2012-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120107328-A1 | GAMMA SECRETASE MODULATORS | BACE1, BACE2, PSEN1 | SMN1; SMN2 1223/4885MEN1 3513/4885KMT2A 3849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.