Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 15/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 15/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15397697 | 0.89 | USP30 (0.39) | PRMT5WDR77 | |
| SCHEMBL6128999 | 0.89 | USP30 (0.39) | PRMT5WDR77 | |
| SCHEMBL6126424 | 0.89 | USP30 (0.39) | PRMT5WDR77 | |
| SCHEMBL14691240 | 0.85 | USP30 (0.39) | PRMT5WDR77 | |
| SCHEMBL14691241 | 0.85 | USP30 (0.39) | PRMT5WDR77 | |
| SCHEMBL6127148 | 0.84 | CYP3A4 (0.53) | CYP3A4 | |
| SCHEMBL7602110 | 0.84 | CYP3A4 (0.53) | CYP3A4 | |
| SCHEMBL6126731 | 0.83 | HCRTR1 (0.42) | HCRTR1HCRTR2 | |
| SCHEMBL15390368 | 0.81 | — | — | |
| SCHEMBL750855 | 0.81 | HCRTR1 (0.46) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2640719-A2 | ANTIVIRAL COMPOUNDS | Gilead Sciences, Inc. (US) | 2013-09-25 | — | — | EP | disclosed |
| EP-2580209-A2 | INHIBITORS OF HCV NS5A PROTEIN | Presidio Pharmaceuticals, Inc. (US) | 2013-04-17 | — | — | EP | disclosed |
| WO-2012068234-A2 | ANTIVIRAL COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2012-05-24 | — | — | WO | disclosed |
| WO-2011156543-A2 | INHIBITORS OF HCV NS5A PROTEIN | PRESIDIO PHARMACEUTICALS, INC. (US) | 2011-12-15 | — | — | WO | disclosed |