Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 13/20 | 0.50 |
| ▸ | KCNQ2 | O43526 | 13/20 | 0.50 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.38 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3698144 | 0.96 | KCNQ3 (0.53) | KCNQ3KCNQ2RIOK2L3MBTL1CYP3A4 | |
| SCHEMBL6126605 | 0.86 | KCNQ3 (0.50) | KCNQ3KCNQ2RIOK2L3MBTL1CYP3A4 | |
| SCHEMBL3700529 | 0.84 | KCNQ3 (0.58) | KCNQ3KCNQ2 | |
| SCHEMBL6126265 | 0.82 | KLK7 (0.45) | KCNQ3KCNQ2 | |
| SCHEMBL3698754 | 0.82 | KCNQ3 (0.53) | KCNQ3KCNQ2RIOK2CYP3A4ADORA2A | |
| SCHEMBL3704262 | 0.81 | KCNQ3 (0.56) | KCNQ3KCNQ2 | |
| SCHEMBL3702539 | 0.79 | KCNQ3 (0.52) | KCNQ3KCNQ2CYP3A4 | |
| SCHEMBL3703285 | 0.78 | KCNQ3 (0.53) | KCNQ3KCNQ2 | |
| SCHEMBL3703085 | 0.78 | KCNQ3 (0.52) | KCNQ3KCNQ2IRAK4 | |
| SCHEMBL3705629 | 0.77 | KCNQ3 (0.55) | KCNQ3KCNQ2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012067822-A1 | PYRAZOLO [1, 5 -A] PYRIMIDIN POTASSIUM CHANNEL MODULATORS | ABBOTT LABORATORIES (US) | 2012-05-24 | — | — | WO | disclosed |