Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
| ▸ | SMYD2 | Q9NRG4 | 2/20 | 0.38 |
| ▸ | NMT1 | P30419 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | F2R | P25116 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2176333 | 0.95 | DYRK1A (0.41) | MKNK1DYRK1ACLK4CLK1DYRK1B | |
| SCHEMBL6126386 | 0.90 | DYRK1A (0.43) | MKNK1DYRK1ACLK4CLK1DYRK1B | |
| SCHEMBL6126286 | 0.89 | SMYD2 (0.45) | MKNK1DYRK1ACLK4CLK1DYRK1B | |
| SCHEMBL6126443 | 0.89 | DYRK1A (0.41) | MKNK1DYRK1ACLK4CLK1DYRK1B | |
| SCHEMBL6126384 | 0.88 | DYRK1A (0.45) | MKNK1DYRK1ACLK4CLK1DYRK1B | |
| SCHEMBL6126121 | 0.88 | SMYD2 (0.46) | MKNK1DYRK1ACLK4CLK1DYRK1B | |
| SCHEMBL6126441 | 0.88 | DYRK1A (0.41) | MKNK1DYRK1ACLK4CLK1DYRK1B | |
| SCHEMBL6126438 | 0.88 | DYRK1A (0.42) | MKNK1DYRK1ACLK4CLK1DYRK1B | |
| SCHEMBL6126224 | 0.86 | DYRK1A (0.44) | MKNK1DYRK1ACLK4CLK1DYRK1B | |
| SCHEMBL2177891 | 0.85 | DYRK1A (0.45) | MKNK1DYRK1ACLK4CLK1DYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8173808-B2 | Substituted naphthalenyl-pyrimidine compounds | ARQULE, INC. (US) | 2012-05-08 | — | — | US | disclosed |
| US-20110166137-A1 | Substituted Naphthalenyl-Pyrimidine Compounds | ARQULE, INC. (US) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166137-A1 | Substituted Naphthalenyl-Pyrimidine Compounds | DPYD, TP53, TYMP | MKNK1 2469/4885DYRK1A 2574/4885CLK4 3301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.