Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 14/20 | 0.49 |
| ▸ | STIM1 | Q13586 | 3/20 | 0.43 |
| ▸ | ORAI1 | Q96D31 | 3/20 | 0.43 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2733191 | 0.80 | IL2 (0.69) | IL2STIM1ORAI1ORAI2MEN1 | |
| SCHEMBL16362415 | 0.75 | IL2 (0.53) | IL2STIM1ORAI1ORAI2MEN1 | |
| SCHEMBL16362392 | 0.73 | IL2 (0.53) | IL2STIM1ORAI1ORAI2MEN1 | |
| SCHEMBL15395893 | 0.71 | IL2 (0.65) | IL2STIM1ORAI1ORAI2MEN1 | |
| SCHEMBL16362094 | 0.71 | IL2 (0.60) | IL2STIM1ORAI1ORAI2MEN1 | |
| SCHEMBL17766343 | 0.70 | IL2 (0.59) | IL2STIM1ORAI1ORAI2MEN1 | |
| SCHEMBL15395848 | 0.70 | IL2 (0.54) | IL2STIM1ORAI1ORAI2MEN1 | |
| SCHEMBL5998475 | 0.70 | IL2 (0.50) | IL2STIM1ORAI1ORAI2MEN1 | |
| SCHEMBL12155494 | 0.70 | IL2 (0.56) | IL2STIM1ORAI1ORAI2MEN1 | |
| SCHEMBL17766395 | 0.70 | IL2 (0.55) | IL2STIM1ORAI1ORAI2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012056478-A1 | OXAZOLE AND ISOXAZOLE CRAC MODULATORS | LUPIN LIMITED (IN) | 2012-05-03 | — | — | WO | disclosed |