Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 13/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.52 |
| ▸ | MTOR | P42345 | 1/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.52 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL188552 | 0.86 | KDM4E (0.53) | PIK3CACREBBPADORA2AADORA2BADORA1 | |
| SCHEMBL1898472 | 0.83 | PIK3CA (0.65) | PIK3CAPIK3CDPIK3CBMTORPIK3CG | |
| SCHEMBL12676338 | 0.81 | PIK3CA (0.62) | PIK3CAPIK3CDPIK3CBMTORPIK3CG | |
| SCHEMBL1899640 | 0.77 | PIK3CA (0.62) | PIK3CAPIK3CDPIK3CBMTORPIK3CG | |
| SCHEMBL1899468 | 0.77 | PIK3CA (0.59) | PIK3CAPIK3CDPIK3CBMTORPIK3CG | |
| SCHEMBL13439818 | 0.77 | PIK3CA (0.53) | PIK3CAPIK3CDPIK3CBMTORPIK3CG | |
| SCHEMBL1899769 | 0.76 | PIK3CA (0.61) | PIK3CAPIK3CDPIK3CBMTORPIK3CG | |
| SCHEMBL1901551 | 0.76 | PIK3CA (0.60) | PIK3CAPIK3CDPIK3CBMTORPIK3CG | |
| SCHEMBL1984787 | 0.76 | PIK3CA (0.53) | PIK3CAPIK3CDPIK3CBMTORPIK3CG | |
| SCHEMBL1896729 | 0.75 | PIK3CA (0.74) | PIK3CAPIK3CDPIK3CBMTORPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940839-B1 | PYRIDOPYRIMIDINONE INHIBITORS OF PI3Kalpha | EXELIXIS INC (US) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012065019-A2 | PYRIDOPYRIMIDINONE INHIBITORS OF P13K ALPHA | EXELIXIS, INC. (US) | 2012-05-18 | — | — | WO | disclosed |
| WO-2007044813-A1 | PYRIDOPYRIMIDINONE INHIBITORS OF PI3Kα | EXELIXIS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |