Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 12/20 | 0.66 |
| ▸ | JAK2 | O60674 | 18/20 | 0.59 |
| ▸ | AXL | P30530 | 2/20 | 0.56 |
| ▸ | MERTK | Q12866 | 2/20 | 0.56 |
| ▸ | TYK2 | P29597 | 1/20 | 0.55 |
| ▸ | JAK3 | P52333 | 1/20 | 0.55 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6127610 | 0.90 | AXL (0.70) | JAK1JAK2AXLMERTKTYK2 | |
| SCHEMBL9894036 | 0.90 | AXL (0.70) | JAK1JAK2AXLMERTKTYK2 | |
| SCHEMBL9893817 | 0.90 | AXL (0.70) | JAK1JAK2AXLMERTKTYK2 | |
| SCHEMBL2396844 | 0.80 | JAK1 (1.00) | JAK1JAK2AXLMERTKTYK2 | |
| SCHEMBL30986012 | 0.80 | JAK1 (1.00) | JAK1JAK2AXLMERTKTYK2 | |
| SCHEMBL9894050 | 0.79 | JAK2 (0.82) | JAK1JAK2AXLMERTKTYK2 | |
| SCHEMBL9894484 | 0.79 | JAK2 (0.82) | JAK1JAK2AXLMERTKTYK2 | |
| SCHEMBL6126998 | 0.79 | JAK2 (0.82) | JAK1JAK2AXLMERTKTYK2 | |
| SCHEMBL6126788 | 0.79 | JAK2 (0.50) | JAK1JAK2AXLMERTKTYK2 | |
| SCHEMBL2392894 | 0.78 | JAK2 (0.81) | JAK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2640723-A1 | CYCLOBUTYL SUBSTITUTED PYRROLOPYRIDINE AND PYRROLOPYRIMIDINE DERIVATIVES AS JAK INHIBITORS | Incyte Corporation (US) | 2013-09-25 | — | — | EP | disclosed |
| WO-2012068450-A1 | CYCLOBUTYL SUBSTITUTED PYRROLOPYRIDINE AND PYRROLOPYRIMIDINE DERIVATIVES AS JAK INHIBITORS | INCYTE CORPORATION (US) | 2012-05-24 | — | — | WO | disclosed |