Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 2/20 | 0.42 |
| ▸ | CKS1B | P61024 | 2/20 | 0.42 |
| ▸ | SKP1 | P63208 | 2/20 | 0.42 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.40 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.40 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1777998 | 0.87 | NAMPT (0.55) | NAMPTKCNH2MAPTLMNA | |
| SCHEMBL31569825 | 0.87 | KCNH2 (0.57) | NAMPTKCNH2MAP4K4KITCKS1B | |
| SCHEMBL3700178 | 0.87 | NAMPT (0.55) | NAMPTKCNH2MAP4K4KITCKS1B | |
| SCHEMBL17109172 | 0.86 | NAMPT (0.55) | NAMPTKCNH2MAP4K4KITCKS1B | |
| SCHEMBL20767890 | 0.84 | NAMPT (0.64) | NAMPTKCNH2CKS1BSKP1SKP2 | |
| SCHEMBL3698553 | 0.83 | KCNH2 (0.61) | NAMPTKCNH2MAP4K4KITMAPT | |
| SCHEMBL15822587 | 0.82 | KCNH2 (0.65) | NAMPTKCNH2MAP4K4KITCKS1B | |
| SCHEMBL13094481 | 0.81 | MAPT (0.51) | NAMPTKCNH2CKS1BSKP1SKP2 | |
| SCHEMBL16306683 | 0.81 | NAMPT (0.51) | NAMPTKCNH2CKS1BSKP1SKP2 | |
| SCHEMBL3076747 | 0.80 | NAMPT (0.60) | NAMPTKCNH2CKS1BSKP1SKP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2640698-A1 | NAMPT AND ROCK INHIBITORS | AbbVie Inc. (US) | 2013-09-25 | — | — | EP | disclosed |
| WO-2012067965-A1 | NAMPT AND ROCK INHIBITORS | ABBOTT LABORATORIES (US) | 2012-05-24 | — | — | WO | disclosed |