Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYRO3 | Q06418 | 2/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | MERTK | Q12866 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 16/20 | 0.38 |
| ▸ | JAK1 | P23458 | 14/20 | 0.38 |
| ▸ | JAK3 | P52333 | 10/20 | 0.34 |
| ▸ | TYK2 | P29597 | 4/20 | 0.34 |
| ▸ | RET | P07949 | 3/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.34 |
| ▸ | PAK4 | O96013 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | LTK | P29376 | 2/20 | 0.34 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.34 |
| ▸ | CLK2 | P49760 | 2/20 | 0.34 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.34 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.34 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.34 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12780156 | 0.90 | TYRO3 (0.42) | TYRO3AXLMERTKJAK2JAK1 | |
| Hydrochloric Acid SCHEMBL1498834 | 0.90 | TYRO3 (0.41) | TYRO3AXLMERTKJAK2JAK1 | |
| SCHEMBL1499019 | 0.89 | AXL (0.46) | TYRO3AXLMERTKJAK2JAK1 | |
| SCHEMBL9897036 | 0.89 | TYRO3 (0.41) | TYRO3AXLMERTKJAK2JAK1 | |
| SCHEMBL100244 | 0.88 | JAK2 (0.45) | TYRO3AXLMERTKJAK2JAK1 | |
| SCHEMBL9898464 | 0.88 | TYRO3 (0.38) | TYRO3AXLMERTKJAK2JAK1 | |
| SCHEMBL1498974 | 0.88 | TYRO3 (0.40) | TYRO3AXLMERTKJAK2JAK1 | |
| SCHEMBL1498925 | 0.86 | TYRO3 (0.44) | TYRO3AXLMERTKJAK2JAK1 | |
| SCHEMBL1498852 | 0.86 | TYRO3 (0.44) | TYRO3AXLMERTKJAK2JAK1 | |
| SCHEMBL30100141 | 0.86 | TYRO3 (0.44) | TYRO3AXLMERTKJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9034884-B2 | Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as JAK inhibitors | INCYTE CORPORATION (US) | 2015-05-19 | — | — | US | disclosed |
| EP-2640725-B1 | HETEROCYCLIC-SUBSTITUTED PYRROLOPYRIDINES AND PYRROLOPYRIMIDINES AS JAK INHIBITORS | INCYTE CORP (US) | 2015-01-07 | — | — | EP | disclosed |
| EP-2640725-A1 | HETEROCYCLIC-SUBSTITUTED PYRROLOPYRIDINES AND PYRROLOPYRIMIDINES AS JAK INHIBITORS | Incyte Corporation (US) | 2013-09-25 | — | — | EP | disclosed |
| US-20120149682-A1 | HETEROCYCLIC-SUBSTITUTED PYRROLOPYRIDINES AND PYRROLOPYRIMIDINES AS JAK INHIBITORS | INCYTE CORPORATION | 2012-06-14 | — | — | US | disclosed |
| WO-2012068440-A1 | HETEROCYCLIC-SUBSTITUTED PYRROLOPYRIDINES AND PYRROLOPYRIMIDINES AS JAK INHIBITORS | INCYTE CORPORATION (US) | 2012-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149682-A1 | HETEROCYCLIC-SUBSTITUTED PYRROLOPYRIDINES AND PYRROLOPYRIMIDINES AS JAK INHIBITORS | JAK2, JAK1, JAK3 | TYRO3 74/4885AXL 355/4885MERTK 662/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.