Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 18/20 | 1.00 |
| ▸ | TUBB4A | P04350 | 10/20 | 0.76 |
| ▸ | TUBB | P07437 | 10/20 | 0.76 |
| ▸ | TUBA3C | P0DPH7 | 10/20 | 0.76 |
| ▸ | TUBA1B | P68363 | 10/20 | 0.76 |
| ▸ | TUBA4A | P68366 | 10/20 | 0.76 |
| ▸ | TUBB4B | P68371 | 10/20 | 0.76 |
| ▸ | TUBB3 | Q13509 | 10/20 | 0.76 |
| ▸ | TUBB2A | Q13885 | 10/20 | 0.76 |
| ▸ | TUBB8 | Q3ZCM7 | 10/20 | 0.76 |
| ▸ | TUBA3E | Q6PEY2 | 10/20 | 0.76 |
| ▸ | TUBA1A | Q71U36 | 10/20 | 0.76 |
| ▸ | TUBA1C | Q9BQE3 | 10/20 | 0.76 |
| ▸ | TUBB6 | Q9BUF5 | 10/20 | 0.76 |
| ▸ | TUBB2B | Q9BVA1 | 10/20 | 0.76 |
| ▸ | BACE1 | P56817 | 1/20 | 0.57 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.57 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.57 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.57 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6129276 | 1.00 | TUBB1 (1.00) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL6129147 | 0.86 | TUBB1 (1.00) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL6129120 | 0.85 | TUBB1 (1.00) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL15675107 | 0.81 | TUBB1 (0.72) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL5700860 | 0.81 | TUBB1 (0.72) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL5608201 | 0.80 | TUBB1 (1.00) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL29778095 | 0.79 | TUBB1 (0.72) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL29778080 | 0.79 | TUBB1 (0.72) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL6129100 | 0.78 | TUBB1 (1.00) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL31032788 | 0.77 | TUBB1 (0.80) | TUBB1TUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050065213-A1 | Combretastatin a-4 derivatives having antineoplastic activity | LAWRENCE NICHOLAS JAMES (GB) | 2005-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050065213-A1 | Combretastatin a-4 derivatives having antineoplastic activity | AURKA, AURKB, HDAC4 | TUBB1 567/4885TUBB4A 61/4885TUBB 472/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.