Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | ILK | Q13418 | 1/20 | 0.36 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7964868 | 0.82 | HTR2C (0.47) | PARP1MEN1KMT2AADORA2AADORA3 | |
| SCHEMBL5619953 | 0.79 | PARP1 (0.65) | PARP1 | |
| SCHEMBL7956610 | 0.78 | HTR2C (0.50) | PARP1MEN1KMT2AMAPK13MAPK9 | |
| Hydrochloric Acid SCHEMBL18614385 | 0.78 | PARP1 (0.64) | PARP1 | |
| SCHEMBL5620715 | 0.77 | PARP1 (0.53) | PARP1PBK | |
| SCHEMBL7966170 | 0.76 | HSD17B10 (0.43) | PARP1MAPTADORA2AADORA2B | |
| SCHEMBL5620666 | 0.76 | PARP1 (0.52) | PARP1PBK | |
| SCHEMBL6129581 | 0.76 | PARP1 (0.65) | PARP1MEN1KMT2AMAPT | |
| SCHEMBL7965946 | 0.75 | CDK1 (0.40) | PARP1MEN1KMT2AMAPK13MAPK9 | |
| SCHEMBL531889 | 0.74 | PARP1 (0.52) | PARP1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188011-B1 | Optimization of ligand affinity for RNA targets using mass spectrometry | ISIS PHARMACEUTICALS, INC. (US) | 2012-05-29 | — | — | US | disclosed |
| US-20050142581-A1 | Microrna as ligands and target molecules | ISIS PHARMACEUTICALS, INC. | 2005-06-30 | — | — | US | disclosed |
| WO-2005023986-A2 | MICRORNA AS LIGANDS AND TARGET MOLECULES | ISIS PHARMACEUTICALS, INC. (US) | 2005-03-17 | — | — | WO | disclosed |
| EP-1183091-A4 | OPTIMIZATION OF LIGAND AFFINITY FOR RNA TARGETS USING MASS SPECTROMETRY | ISIS PHARMACEUTICALS INC (US) | 2005-03-02 | — | — | EP | disclosed |
| US-6770486-B1 | IDENTIFICATION OF LIGAND COMPOUNDS THAT BIND TO TARGET MOLECULES SUCH AS PROTEINS OR STRUCTURED RNA WITH AS LITTLE AS MILLIMOLAR (MM) AFFINITY USING MASS SPECTROMETRY | ISIS PHARMACEUTICALS, INC. | 2004-08-03 | — | — | US | disclosed |
| EP-1183091-A1 | OPTIMIZATION OF LIGAND AFFINITY FOR RNA TARGETS USING MASS SPECTROMETRY | ISIS PHARMACEUTICALS, INC. (US) | 2002-03-06 | — | — | EP | disclosed |
| WO-2001058573-A1 | OPTIMIZATION OF LIGAND AFFINITY FOR RNA TARGETS USING MASS SPECTROMETRY | ISIS PHARMACEUTICALS, INC. (US) | 2001-08-16 | — | — | WO | disclosed |