Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.46 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.39 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.39 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.39 |
| ▸ | OTC | P00480 | 1/20 | 0.37 |
| ▸ | NPY4R | P50391 | 5/20 | 0.36 |
| ▸ | NPY1R | P25929 | 3/20 | 0.36 |
| ▸ | NOS2 | P35228 | 5/20 | 0.36 |
| ▸ | NOS1 | P29475 | 4/20 | 0.36 |
| ▸ | NOS3 | P29474 | 3/20 | 0.36 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NPY2R | P49146 | 2/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL10876829 | 0.97 | GSR (0.43) | GSRGNAI3GNAO1GNAI1OTC | |
| Arginine SCHEMBL904454 | 0.94 | OTC (0.41) | GSROTCNPY4RNPY1RNOS2 | |
| SCHEMBL1965668 | 0.92 | NPY4R (0.38) | OTCNPY4RNPY1RNOS2NOS1 | |
| Arginine SCHEMBL9551434 | 0.90 | GSR (0.37) | GSRGNAI3GNAO1GNAI1OTC | |
| Arginine SCHEMBL17889143 | 0.86 | GSR (0.34) | GSRGNAI3GNAO1GNAI1NPY4R | |
| Arginine SCHEMBL15941088 | 0.86 | GSR (0.34) | GSRGNAI3GNAO1GNAI1NPY4R | |
| Arginine SCHEMBL9395050 | 0.86 | GSR (0.53) | GSRGNAI3GNAO1GNAI1OTC | |
| Arginine SCHEMBL1533652 | 0.86 | GSR (0.53) | GSRGNAI3GNAO1GNAI1OTC | |
| Arginine SCHEMBL1533521 | 0.86 | GSR (0.53) | GSRGNAI3GNAO1GNAI1OTC | |
| Arginine SCHEMBL8844996 | 0.86 | GSR (0.53) | GSRGNAI3GNAO1GNAI1OTC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1315752-A4 | MODIFIED PROTEINS, ISOLATED NOVEL PEPTIDES, AND USES THEREOF | UNIV AUSTRALIAN (AU) | 2005-07-06 | — | — | EP | disclosed |
| US-20040091964-A1 | Modified proteins, isolated novel peptides,and uses thereof | BOARD PHILLIP (AU) | 2004-05-13 | — | — | US | disclosed |
| EP-1315752-A1 | MODIFIED PROTEINS, ISOLATED NOVEL PEPTIDES, AND USES THEREOF | THE AUSTRALIAN NATIONAL UNIVERSITY (AU) | 2003-06-04 | — | — | EP | disclosed |
| WO-2002018438-A9 | MODIFIED PROTEINS, ISOLATED NOVEL PEPTIDES, AND USES THEREOF | UNIV AUSTRALIAN (AU) | 2002-05-30 | — | — | WO | disclosed |
| WO-2002018438-A1 | MODIFIED PROTEINS, ISOLATED NOVEL PEPTIDES, AND USES THEREOF | THE AUSTRALIAN NATIONAL UNIVERSITY (AU) | 2002-03-07 | — | — | WO | disclosed |