Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 1/20 | 0.76 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.76 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.76 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.76 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.76 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ESRRA | P11474 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | MOGAT2 | Q3SYC2 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Flindokalner SCHEMBL4056222 | 0.86 | KCNQ3 (1.00) | KCNQ3KCNQ2KCNQ4KCNMA1KCNQ5 | |
| Flindokalner SCHEMBL30322726 | 0.86 | KCNQ3 (1.00) | KCNQ3KCNQ2KCNQ4KCNMA1KCNQ5 | |
| Flindokalner SCHEMBL5144502 | 0.86 | KCNQ3 (1.00) | KCNQ3KCNQ2KCNQ4KCNMA1KCNQ5 | |
| SCHEMBL24051652 | 0.86 | KCNQ3 (0.76) | KCNQ3KCNQ2KCNQ4KCNMA1KCNQ5 | |
| Flindokalner SCHEMBL4877314 | 0.86 | KCNQ3 (1.00) | KCNQ3KCNQ2KCNQ4KCNMA1KCNQ5 | |
| SCHEMBL24051653 | 0.86 | KCNQ3 (0.76) | KCNQ3KCNQ2KCNQ4KCNMA1KCNQ5 | |
| Flindokalner SCHEMBL29388740 | 0.86 | KCNQ3 (1.00) | KCNQ3KCNQ2KCNQ4KCNMA1KCNQ5 | |
| SCHEMBL24051215 | 0.86 | KCNQ3 (0.76) | KCNQ3KCNQ2KCNQ4KCNMA1KCNQ5 | |
| SCHEMBL5858002 | 0.85 | KCNQ3 (0.74) | KCNQ3KCNQ2KCNQ4KCNMA1KCNQ5 | |
| SCHEMBL24051694 | 0.83 | KCNQ3 (0.71) | KCNQ3KCNQ2KCNQ4KCNMA1KCNQ5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1330426-A4 | SELECTIVE MAXI-K- POTASSIUM CHANNEL OPENERS FUNCTIONAL UNDER CONDITIONS OF HIGH INTRACELLULAR CALCIUM CONCENTRATION, METHODS AND USES THEREOF | BRISTOL MYERS SQUIBB CO (US) | 2005-09-14 | — | — | EP | claimed |
| US-20050043293-A1 | Selective maxi-K potassium channel openers functional under conditions of high intracellular calcium concentration, methods and uses thereof | GRIBKOFF VALENTIN K (US) | 2005-02-24 | — | — | US | claimed |
| EP-1330426-A1 | SELECTIVE MAXI-K- POTASSIUM CHANNEL OPENERS FUNCTIONAL UNDER CONDITIONS OF HIGH INTRACELLULAR CALCIUM CONCENTRATION, METHODS AND USES THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-07-30 | — | — | EP | claimed |
| WO-2002030868-A1 | SELECTIVE MAXI-K- POTASSIUM CHANNEL OPENERS FUNCTIONAL UNDER CONDITIONS OF HIGH INTRACELLULAR CALCIUM CONCENTRATION, METHODS AND USES THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-04-18 | — | — | WO | claimed |
| US-20020045566-A1 | Selective maxi-K potassium channel openers functional under conditions of high intracellular calcium concentration, methods and uses thereof | BRISTOL-MYERS SQUIBB COMPANY | 2002-04-18 | — | — | US | claimed |
| EP-1330426-A4 | SELECTIVE MAXI-K- POTASSIUM CHANNEL OPENERS FUNCTIONAL UNDER CONDITIONS OF HIGH INTRACELLULAR CALCIUM CONCENTRATION, METHODS AND USES THEREOF | BRISTOL MYERS SQUIBB CO (US) | 2005-09-14 | — | — | EP | disclosed |
| US-20050043293-A1 | Selective maxi-K potassium channel openers functional under conditions of high intracellular calcium concentration, methods and uses thereof | GRIBKOFF VALENTIN K (US) | 2005-02-24 | — | — | US | disclosed |
| EP-1330426-A1 | SELECTIVE MAXI-K- POTASSIUM CHANNEL OPENERS FUNCTIONAL UNDER CONDITIONS OF HIGH INTRACELLULAR CALCIUM CONCENTRATION, METHODS AND USES THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-07-30 | — | — | EP | disclosed |
| WO-2002030868-A1 | SELECTIVE MAXI-K- POTASSIUM CHANNEL OPENERS FUNCTIONAL UNDER CONDITIONS OF HIGH INTRACELLULAR CALCIUM CONCENTRATION, METHODS AND USES THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-04-18 | — | — | WO | disclosed |