Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 11/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.41 |
| ▸ | MAPT | P10636 | 10/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5364134 | 0.81 | MAPT (0.53) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL5364129 | 0.81 | MAPT (0.53) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL6130277 | 0.75 | MAPT (0.47) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL6130315 | 0.73 | KMT2A (0.41) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL6130287 | 0.73 | KMT2A (0.40) | MEN1KMT2AMAPTNPC1GAA | |
| SCHEMBL5362822 | 0.71 | MAPT (0.64) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL5362825 | 0.71 | MAPT (0.64) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL5364913 | 0.70 | MAPT (0.72) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL5364907 | 0.70 | MAPT (0.72) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL5364167 | 0.69 | MAPT (0.71) | MEN1KMT2AMAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349613-A4 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2005-09-21 | — | — | EP | disclosed |
| EP-1349613-A2 | THROMBOPOIETIN MIMETICS | SmithKline Beecham Corporation (US) | 2003-10-08 | — | — | EP | disclosed |
| WO-2002049413-A2 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-06-27 | — | — | WO | disclosed |