Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.79 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.72 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.69 |
| ▸ | MAOB | P27338 | 1/20 | 0.68 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.63 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.60 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.59 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.58 |
| ▸ | FAAH | O00519 | 1/20 | 0.58 |
| ▸ | CNR2 | P34972 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | GUSB | P08236 | 1/20 | 0.57 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.56 |
| ▸ | BCHE | P06276 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6951340 | 0.88 | PTPN1 (1.00) | PTPN1NR4A2SMPD1MAOBSRD5A2 | |
| SCHEMBL3442550 | 0.88 | PTPN1 (0.75) | PTPN1NR4A2SMPD1MAOBSRD5A2 | |
| SCHEMBL13427458 | 0.88 | MEN1 (0.71) | PTPN1NR4A2SMPD1MAOBSRD5A2 | |
| SCHEMBL7531827 | 0.87 | PTPN1 (0.73) | PTPN1NR4A2SMPD1MAOBSRD5A2 | |
| SCHEMBL7901142 | 0.86 | NR4A2 (0.74) | PTPN1NR4A2SMPD1MAOBSRD5A2 | |
| SCHEMBL1800966 | 0.86 | NR4A2 (0.74) | PTPN1NR4A2SMPD1MAOBSRD5A2 | |
| SCHEMBL1438839 | 0.85 | NR4A2 (0.72) | PTPN1NR4A2SMPD1MAOBSRD5A2 | |
| SCHEMBL7337987 | 0.85 | NR4A2 (0.72) | PTPN1NR4A2SMPD1MAOBSRD5A2 | |
| SCHEMBL2152475 | 0.85 | MAOB (0.73) | PTPN1NR4A2SMPD1MAOBSRD5A2 | |
| SCHEMBL31130421 | 0.85 | PTPN1 (0.78) | PTPN1NR4A2SMPD1MAOBSRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575940-A1 | 2,4,6-TRISUBSTITUTED PYRIMIDINES AS PHOSPHOTIDYLINOSITOL (PI) 3-KINASE INHIBITORS AND THEIR USE IN THE TREATMENT OF CANCER | CHIRON CORPORATION (US) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004048365-A1 | 2,4,6-TRISUBSTITUTED PYRIMIDINES AS PHOSPHOTIDYLINOSITOL (PI) 3-KINASE INHIBITORS AND THEIR USE IN THE TREATMENT OF CANCER | CHIRON CORPORATION (US) | 2004-06-10 | — | — | WO | disclosed |