Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 16/20 | 1.00 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.82 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.82 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.82 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.65 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2470377 | 0.96 | PIK3CA (0.93) | PIK3CAPIK3CDPIK3CBPIK3CGROCK2 | |
| SCHEMBL2468192 | 0.92 | PIK3CA (0.84) | PIK3CAPIK3CDPIK3CBPIK3CGROCK2 | |
| SCHEMBL1821854 | 0.90 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1822195 | 0.90 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3CBPIK3CGROCK2 | |
| SCHEMBL1821406 | 0.88 | PIK3CA (0.79) | PIK3CAPIK3CDPIK3CBPIK3CGROCK2 | |
| SCHEMBL1822977 | 0.88 | PIK3CA (0.78) | PIK3CAPIK3CDPIK3CBPIK3CGROCK2 | |
| SCHEMBL12196643 | 0.87 | PIK3CA (0.77) | PIK3CAPIK3CDPIK3CBPIK3CGROCK2 | |
| SCHEMBL1819355 | 0.87 | PIK3CA (0.77) | PIK3CAPIK3CDPIK3CBPIK3CGROCK2 | |
| SCHEMBL1819551 | 0.84 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3CBPIK3CGROCK2 | |
| SCHEMBL1819822 | 0.84 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3CBPIK3CGROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575940-A1 | 2,4,6-TRISUBSTITUTED PYRIMIDINES AS PHOSPHOTIDYLINOSITOL (PI) 3-KINASE INHIBITORS AND THEIR USE IN THE TREATMENT OF CANCER | CHIRON CORPORATION (US) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004048365-A1 | 2,4,6-TRISUBSTITUTED PYRIMIDINES AS PHOSPHOTIDYLINOSITOL (PI) 3-KINASE INHIBITORS AND THEIR USE IN THE TREATMENT OF CANCER | CHIRON CORPORATION (US) | 2004-06-10 | — | — | WO | disclosed |