Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.66 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.66 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.66 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6131800 | 0.90 | PIK3CA (0.70) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL6131796 | 0.89 | PIK3CA (0.71) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1821609 | 0.83 | PIK3CA (0.66) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1821854 | 0.81 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL2493156 | 0.79 | PIK3CA (0.63) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1822175 | 0.78 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL6131803 | 0.78 | PIK3CA (0.56) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1822731 | 0.77 | PIK3CA (0.63) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1821106 | 0.75 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1821372 | 0.75 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575940-A1 | 2,4,6-TRISUBSTITUTED PYRIMIDINES AS PHOSPHOTIDYLINOSITOL (PI) 3-KINASE INHIBITORS AND THEIR USE IN THE TREATMENT OF CANCER | CHIRON CORPORATION (US) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004048365-A1 | 2,4,6-TRISUBSTITUTED PYRIMIDINES AS PHOSPHOTIDYLINOSITOL (PI) 3-KINASE INHIBITORS AND THEIR USE IN THE TREATMENT OF CANCER | CHIRON CORPORATION (US) | 2004-06-10 | — | — | WO | disclosed |