⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19541950 | 0.75 | — | — | |
| SCHEMBL389016 | 0.72 | — | — | |
| SCHEMBL42538 | 0.69 | — | — | |
| SCHEMBL2517088 | 0.69 | — | — | |
| SCHEMBL879224 | 0.69 | — | — | |
| SCHEMBL2391330 | 0.69 | — | — | |
| SCHEMBL2955368 | 0.69 | — | — | |
| SCHEMBL15061491 | 0.67 | — | — | |
| SCHEMBL95874 | 0.67 | — | — | |
| SCHEMBL7648869 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884868-B1 | Cyclic hexapeptides having antibiotic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2005-04-26 | — | — | US | claimed |
| EP-1173472-A1 | CYCLIC HEXAPEPTIDES HAVING ANTIBIOTIC ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-01-23 | — | — | EP | claimed |
| WO-2000064927-A1 | CYCLIC HEXAPEPTIDES HAVING ANTIBIOTIC ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-11-02 | — | — | WO | claimed |
| US-9931353-B2 | Method for treating cerebral amyloid angiopathy using pharmacological chaperones to increase the activity of gangliosidases | AMICUS THERAPEUTICS, INC. (US) | 2018-04-03 | — | — | US | disclosed |
| EP-2957295-B1 | METHOD FOR TREATING ALZHEIMER'S DISEASE USING PHARMACOLOGICAL CHAPERONES TO INCREASE THE ACTIVITY OF GANGLIOSIDASES | AMICUS THERAPEUTICS INC (US) | 2017-08-02 | — | — | EP | disclosed |
| EP-2273996-B1 | HUMAN CARDIOVASCULAR PROGENITOR CELLS | MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIV (US) | 2017-02-22 | — | — | EP | disclosed |
| EP-2599508-B1 | Adhesive complex coacervates and methods of making and using thereof | UNIV UTAH RES FOUND (US) | 2016-05-25 | — | — | EP | disclosed |
| US-20150374733-A1 | Method for Treating Cerebral Amyloid Angiopathy Using Pharmacological Chaperones to Increase the Activity of Gangliosidases | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2015-12-31 | — | — | US | disclosed |
| EP-2957295-A1 | METHOD FOR TREATING ALZHEIMER'S DISEASE USING PHARMACOLOGICAL CHAPERONES TO INCREASE THE ACTIVITY OF GANGLIOSIDASES | Amicus Therapeutics, Inc. (US) | 2015-12-23 | — | — | EP | disclosed |
| US-9210636-B2 | System and method for indicating local IP access support via NAS signaling | MEDIATEK INC. (TW) | 2015-12-08 | — | — | US | disclosed |
| EP-2490712-B1 | METHOD FOR TREATING ALZHEIMER'S DISEASE USING PHARMACOLOGICAL CHAPERONES TO INCREASE THE ACTIVITY OF GANGLIOSIDASES | AMICUS THERAPEUTICS INC (US) | 2015-07-08 | — | — | EP | disclosed |
| US-9044437-B2 | Method for treating alzheimer's disease using pharmacological chaperones to increase the activity of gangliosidases | AMICUS THERAPEUTICS, INC. (US) | 2015-06-02 | — | — | US | disclosed |
| US-20120309788-A1 | Method for Treating Alzheimer's Disease Using Pharmacological Chaperones To Increase The Activity of Gangliosidases | AMICUS THERAPEUTICS, INC. (US) | 2012-12-06 | — | — | US | disclosed |
| WO-2006113942-A2 | METHOD OF INHIBITING CATHEPSIN ACTIVITY | SCHERING CORPORATION (US) | 2006-10-26 | — | — | WO | disclosed |