Ethyl Fumarate

Ethyl Fumarate

SCHEMBL6133836

C=C(CC(CC)CCCC)C(=O)OCC.C=C(O)C(=O)OCC.CCOC(=O)/C=C\C(=O)O

nearest known ligand 0.48

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 5/20 0.48
TSHR P16473 2/20 0.42
TDP1 Q9NUW8 2/20 0.36
ATM Q13315 2/20 0.35
CYP3A4 P08684 2/20 0.35
ALDH1A1 P00352 3/20 0.33
RECQL P46063 1/20 0.33
ACHE P22303 1/20 0.33
BACE1 P56817 1/20 0.33
CA2 P00918 3/20 0.32
NPSR1 Q6W5P4 1/20 0.31
LMNA P02545 1/20 0.31
MAPK1 P28482 1/20 0.31
MAPT P10636 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ethyl Fumarate SCHEMBL6134352 0.87 TSHR (0.48) HCAR2TSHRTDP1ATMCYP3A4
SCHEMBL16412765 0.84 TSHR (0.47) TSHRTDP1ATMCYP3A4ALDH1A1
Maleic Acid SCHEMBL5022406 0.82 TSHR (0.43) HCAR2TSHRTDP1ATMCYP3A4
SCHEMBL28492774 0.80 TSHR (0.43) TSHRTDP1ATMCYP3A4ALDH1A1
Acrylic Acid Ethyl Ester SCHEMBL158380 0.77 TSHR (0.74) HCAR2TSHRTDP1ATMCYP3A4
SCHEMBL285227 0.76 TSHR (0.49) HCAR2TSHRTDP1ATMCYP3A4
Acrylic Acid SCHEMBL21925310 0.76 TSHR (0.61) TSHRTDP1ATMCYP3A4ALDH1A1
SCHEMBL1759450 0.76 TSHR (0.47) TSHRTDP1ATMCYP3A4ALDH1A1
Ethyl Fumarate SCHEMBL1602734 0.76 HCAR2 (0.42) HCAR2TSHRTDP1ATMCYP3A4
Acrylic Acid SCHEMBL10615547 0.76 TSHR (0.72) HCAR2TSHRTDP1ATMCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050226919-A1 Device for transdermal administration for the treatment of urinary tract disorders UCB PHARMA GMBH (DE) 2005-10-13 US disclosed
EP-1293198-B1 Device for transdermal administration for the treatment of urinary tract disorders SANOL ARZNEI SCHWARZ GMBH (DE) 2005-02-09 EP disclosed
WO-2003024432-A2 DEVICE FOR TRANSDERMAL ADMINISTRATION FOR THE TREATMENT OF URINARY TRACT DISORDERS SCHWARZ PHARMA AG (DE) 2003-03-27 WO disclosed
EP-1293198-A1 Device for transdermal administration for the treatment of urinary tract disorders SCHWARZ PHARMA AG (DE) 2003-03-19 EP disclosed
US-5393529-A Sustained release LTS LOHMANN THERAPIE-SYSTEME GMBH & CO. KG (DE) 1995-02-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050226919-A1 Device for transdermal administration for the treatment of urinary tract disorders AR, CYP17A1, TACR1 HCAR2 504/4885TSHR 465/4885TDP1 4163/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.