SCHEMBL6134244

SCHEMBL6134244

CCCCCS(=O)(=O)NC(=O)c1ccc2nc(C)n(Cc3ccc(N(C)C(=O)O)cc3Cl)c2n1

nearest known ligand 0.57

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PPARG P37231 19/20 0.57
ALDH1A1 P00352 1/20 0.36
MAPT P10636 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6493976 0.92 PPARG (0.55) PPARGALDH1A1MAPTSMN1; SMN2
SCHEMBL6494529 0.92 PPARG (0.55) PPARGALDH1A1MAPT
SCHEMBL6491314 0.91 PPARG (0.58) PPARGALDH1A1MAPTSMN1; SMN2
SCHEMBL6493813 0.91 PPARG (0.54) PPARG
SCHEMBL6135445 0.91 PPARG (0.57) PPARGALDH1A1MAPTSMN1; SMN2
SCHEMBL6501192 0.91 PPARG (0.57) PPARGALDH1A1MAPTSMN1; SMN2
SCHEMBL6491907 0.91 PPARG (0.57) PPARGALDH1A1MAPTSMN1; SMN2
SCHEMBL6495645 0.90 PPARG (0.53) PPARG
SCHEMBL6501817 0.90 PPARG (0.53) PPARG
SCHEMBL6493015 0.89 PPARG (0.52) PPARGALDH1A1MAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050197376-A1 Concomitant drugs FUJISAWA PHARMACEUTICAL CO. LTD. (JP) 2005-09-08 US claimed
US-20050197376-A1 Concomitant drugs FUJISAWA PHARMACEUTICAL CO. LTD. (JP) 2005-09-08 US disclosed