SCHEMBL6134770

SCHEMBL6134770

O=C(O)CCNC(=O)c1ccc(CN(c2ccc3c(c2)CCC3)c2nc(-c3ccc(F)cc3F)cs2)cc1

nearest known ligand 0.73

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GCGR P47871 20/20 0.73
GIPR P48546 17/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2647989 0.92 GCGR (0.74) GCGRGIPR
SCHEMBL2646863 0.90 GCGR (0.86) GCGRGIPR
SCHEMBL2647626 0.87 GCGR (0.81) GCGRGIPR
SCHEMBL9071205 0.87 GCGR (0.85) GCGRGIPR
SCHEMBL2647373 0.87 GCGR (0.70) GCGRGIPR
SCHEMBL2648086 0.86 GCGR (0.81) GCGRGIPR
SCHEMBL9071170 0.86 GCGR (0.70) GCGRGIPR
SCHEMBL2648474 0.86 GCGR (0.78) GCGRGIPR
SCHEMBL2666003 0.85 GCGR (0.85) GCGRGIPR
SCHEMBL2665830 0.84 GCGR (0.73) GCGRGIPR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6881746-B2 Glucagon antagonists/inverse agonists NOVO NORDICK A/S (DK) 2005-04-19 US disclosed