Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 3/20 | 0.71 |
| ▸ | CDC7 | O00311 | 4/20 | 0.62 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.62 |
| ▸ | JAK2 | O60674 | 4/20 | 0.55 |
| ▸ | GAA | P10253 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | CHUK | O15111 | 2/20 | 0.49 |
| ▸ | JAK3 | P52333 | 3/20 | 0.47 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.46 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3507692 | 0.97 | IKBKB (0.67) | IKBKBCDC7DBF4JAK2GAA | |
| SCHEMBL611912 | 0.87 | GAA (0.73) | IKBKBCDC7DBF4JAK2GAA | |
| SCHEMBL3508553 | 0.86 | IKBKB (0.54) | IKBKBCDC7DBF4JAK2GAA | |
| SCHEMBL4197079 | 0.83 | CDC7 (0.58) | IKBKBCDC7DBF4JAK2MEN1 | |
| SCHEMBL3510525 | 0.83 | IKBKB (1.00) | IKBKBJAK2GAAALDH1A1MEN1 | |
| SCHEMBL3507771 | 0.81 | IKBKB (0.73) | IKBKBJAK2GAAALDH1A1MEN1 | |
| SCHEMBL3508467 | 0.80 | IKBKB (0.71) | IKBKBJAK2GAAALDH1A1MEN1 | |
| SCHEMBL5898698 | 0.80 | IKBKB (0.71) | IKBKBJAK2GAAALDH1A1MEN1 | |
| SCHEMBL1428022 | 0.80 | IKBKB (0.71) | IKBKBJAK2GAAALDH1A1MEN1 | |
| SCHEMBL1428039 | 0.80 | IKBKB (0.71) | IKBKBJAK2GAAALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403857-B1 | THIENOPYRIMIDINE AS CDC7 KINASE INHIBITORS | TAKEDA PHARMACEUTICAL (JP) | 2013-12-04 | — | — | EP | disclosed |
| US-20120040981-A1 | THIENOPYRIMIDINE AS CDC7 KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-02-16 | — | — | US | disclosed |
| EP-2403857-A1 | THIENOPYRIMIDINE AS CDC7 KINASE INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2012-01-11 | — | — | EP | disclosed |
| WO-2010101302-A1 | THIENOPYRIMIDINE AS CDC7 KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040981-A1 | THIENOPYRIMIDINE AS CDC7 KINASE INHIBITORS | CDC7, CDK7, DTYMK | IKBKB 993/4885CDC7 1/4885DBF4 593/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.