Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 16/20 | 0.75 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.75 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5344524 | 0.91 | PDE4A (0.77) | PDE4AKCNH2PDE4BPDE4DPDE4C | |
| SCHEMBL5342005 | 0.86 | PDE4A (0.72) | PDE4AKCNH2PDE4BPDE4DPDE4C | |
| SCHEMBL5339716 | 0.86 | PDE4A (1.00) | PDE4AKCNH2PDE4BPDE4DPDE4C | |
| SCHEMBL6135868 | 0.84 | KCNH2 (0.71) | PDE4AKCNH2PDE4BPDE4DPDE4C | |
| SCHEMBL6135783 | 0.82 | PDE4A (0.77) | PDE4AKCNH2PDE4BPDE4DPDE4C | |
| SCHEMBL6135714 | 0.80 | PDE4A (0.64) | PDE4AKCNH2PDE4BPDE4DPDE4C | |
| SCHEMBL5336761 | 0.79 | PDE4A (0.76) | PDE4AKCNH2PDE4BPDE4DPDE4C | |
| SCHEMBL1565705 | 0.79 | PDE4A (1.00) | PDE4AKCNH2PDE4BPDE4DPDE4C | |
| SCHEMBL1566572 | 0.76 | PDE4A (0.71) | PDE4AKCNH2PDE4BPDE4DPDE4C | |
| SCHEMBL5343675 | 0.76 | PDE4A (0.81) | PDE4AKCNH2PDE4BPDE4DPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1592419-A1 | USE OF PHOSPHODIESTERASE-4 INHIBITORS AS ENHANCERS OF COGNITION | Merck Frosst Canada & Co. (CA) | 2005-11-09 | — | — | EP | claimed |
| WO-2004047836-A1 | USE OF PHOSPHODIESTERASE-4 INHIBITORS AS ENHANCERS OF COGNITION | MERCK FROSST CANADA & CO. (CA) | 2004-06-10 | — | — | WO | claimed |