Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 16/20 | 0.60 |
| ▸ | CYSLTR1 | Q9Y271 | 16/20 | 0.60 |
| ▸ | PPARG | P37231 | 2/20 | 0.54 |
| ▸ | PPARD | Q03181 | 2/20 | 0.54 |
| ▸ | PPARA | Q07869 | 2/20 | 0.54 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6137013 | 0.85 | PPARG (0.68) | CYSLTR2CYSLTR1PPARGPPARDPPARA | |
| SCHEMBL6136969 | 0.85 | CYSLTR2 (0.47) | CYSLTR2CYSLTR1PPARGPPARDPPARA | |
| SCHEMBL6137008 | 0.81 | PPARG (0.73) | CYSLTR2CYSLTR1PPARGPPARDPPARA | |
| SCHEMBL6137187 | 0.81 | CYSLTR2 (0.75) | CYSLTR2CYSLTR1PPARGPPARDPPARA | |
| SCHEMBL9733439 | 0.79 | CYSLTR2 (0.76) | CYSLTR2CYSLTR1PPARGPPARDPPARA | |
| SCHEMBL6137005 | 0.79 | GRM2 (0.66) | CYSLTR2CYSLTR1PPARGPPARDPPARA | |
| SCHEMBL11073023 | 0.78 | CYSLTR2 (0.73) | CYSLTR2CYSLTR1PPARGPPARDPPARA | |
| SCHEMBL10358954 | 0.78 | CYSLTR1 (0.60) | CYSLTR2CYSLTR1PPARGPPARDPPARA | |
| SCHEMBL9733470 | 0.77 | CYSLTR2 (0.64) | CYSLTR2CYSLTR1PPARGPPARDPPARA | |
| SCHEMBL9733653 | 0.76 | CYSLTR2 (0.75) | CYSLTR2CYSLTR1PPARGPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1011651-B1 | METHOD OF TREATING DIABETES AND RELATED DISEASE STATES | MERCK & CO INC (US) | 2005-04-27 | — | — | EP | claimed |
| EP-1011651-A4 | METHOD OF TREATING DIABETES AND RELATED DISEASE STATES | MERCK & CO INC (US) | 2000-06-28 | — | — | EP | claimed |
| EP-1011651-A1 | METHOD OF TREATING DIABETES AND RELATED DISEASE STATES | Merck & Co., Inc. (US) | 2000-06-28 | — | — | EP | claimed |
| US-5847008-A | Method of treating diabetes and related disease states | MERCK & CO., INC. (US) | 1998-12-08 | — | — | US | claimed |
| WO-1997027847-A1 | METHOD OF TREATING DIABETES AND RELATED DISEASE STATES | MERCK & CO., INC. (US) | 1997-08-07 | — | — | WO | claimed |
| EP-0106565-B1 | LEUKOTRIENE ANTAGONISTS, THEIR PRODUCTION, AND COMPOSITIONS CONTAINING THEM | MERCK FROSST CANADA INC. (CA) | 1986-09-10 | — | — | EP | claimed |
| EP-0106565-A1 | Leukotriene antagonists, their production, and compositions containing them | MERCK FROSST CANADA INC. (CA) | 1984-04-25 | — | — | EP | claimed |
| EP-1011651-B1 | METHOD OF TREATING DIABETES AND RELATED DISEASE STATES | MERCK & CO INC (US) | 2005-04-27 | — | — | EP | disclosed |
| EP-1011651-A4 | METHOD OF TREATING DIABETES AND RELATED DISEASE STATES | MERCK & CO INC (US) | 2000-06-28 | — | — | EP | disclosed |
| EP-1011651-A1 | METHOD OF TREATING DIABETES AND RELATED DISEASE STATES | Merck & Co., Inc. (US) | 2000-06-28 | — | — | EP | disclosed |
| US-6020382-A | Method of treating diabetes and related disease states | MERCK & CO., INC. (US) | 2000-02-01 | — | — | US | disclosed |
| US-5847008-A | Method of treating diabetes and related disease states | MERCK & CO., INC. (US) | 1998-12-08 | — | — | US | disclosed |
| WO-1997027847-A1 | METHOD OF TREATING DIABETES AND RELATED DISEASE STATES | MERCK & CO., INC. (US) | 1997-08-07 | — | — | WO | disclosed |
| EP-0106565-B1 | LEUKOTRIENE ANTAGONISTS, THEIR PRODUCTION, AND COMPOSITIONS CONTAINING THEM | MERCK FROSST CANADA INC. (CA) | 1986-09-10 | — | — | EP | disclosed |
| EP-0106565-A1 | Leukotriene antagonists, their production, and compositions containing them | MERCK FROSST CANADA INC. (CA) | 1984-04-25 | — | — | EP | disclosed |