Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 12/20 | 0.37 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.32 |
| ▸ | FLT1 | P17948 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27524919 | 0.92 | IDO1 (0.40) | IDO1MEN1KMT2ATDP1MAP2K1 | |
| SCHEMBL5988559 | 0.85 | IDO1 (0.55) | IDO1MEN1KMT2ATDP1MAP2K1 | |
| SCHEMBL5988797 | 0.83 | IDO1 (0.45) | IDO1MEN1KMT2ATDP1MAP2K1 | |
| SCHEMBL27524920 | 0.82 | IDO1 (0.42) | IDO1MEN1KMT2ATDP1MAP2K1 | |
| SCHEMBL6138125 | 0.82 | IDO1 (0.41) | IDO1MEN1KMT2ATDP1MAP2K1 | |
| SCHEMBL5988532 | 0.81 | IDO1 (0.45) | IDO1MEN1KMT2ATDP1MAP2K1 | |
| SCHEMBL6137927 | 0.80 | IDO1 (0.40) | IDO1MEN1KMT2ATDP1MAP2K1 | |
| SCHEMBL6137799 | 0.80 | IDO1 (0.40) | IDO1MEN1KMT2ATDP1MAP2K1 | |
| SCHEMBL27477193 | 0.78 | CSF1R (0.41) | MEN1KMT2A | |
| SCHEMBL6137796 | 0.78 | IDO1 (0.42) | IDO1MEN1KMT2ATDP1MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144385-B1 | BENZOHETEROCYCLES AND THEIR USE AS MEK INHIBITORS | WARNER LAMBERT CO (US) | 2005-08-17 | — | — | EP | claimed |