Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Lamotrigine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A known ✓ | Q15858 | 13/20 | 0.83 |
| ▸ | SCN4A known ✓ | P35499 | 1/20 | 0.83 |
| ▸ | SCN5A known ✓ | Q14524 | 1/20 | 0.83 |
| ▸ | SCN2A known ✓ | Q99250 | 1/20 | 0.83 |
| ▸ | SCN3A known ✓ | Q9NY46 | 1/20 | 0.83 |
| ▸ | SCN10A known ✓ | Q9Y5Y9 | 1/20 | 0.83 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.83 |
| ▸ | MAOA | P21397 | 1/20 | 0.83 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.83 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.83 |
| ▸ | BLM | P54132 | 1/20 | 0.83 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.83 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.83 |
| ▸ | PTPN11 | Q06124 | 5/20 | 0.50 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lamotrigine SCHEMBL3976541 | 0.93 | SCN9A (0.91) | SCN9ACYP2D6MAOAMAPK1ADRA1A | |
| Lamotrigine SCHEMBL29360953 | 0.91 | SCN9A (1.00) | SCN9ACYP2D6MAOAMAPK1ADRA1A | |
| Lamotrigine SCHEMBL35439 | 0.91 | SCN9A (1.00) | SCN9ACYP2D6MAOAMAPK1ADRA1A | |
| Lamotrigine SCHEMBL722975 | 0.91 | SCN9A (1.00) | SCN9ACYP2D6MAOAMAPK1ADRA1A | |
| Lamotrigine SCHEMBL29801510 | 0.91 | SCN9A (1.00) | SCN9ACYP2D6MAOAMAPK1ADRA1A | |
| Lamotrigine SCHEMBL17372723 | 0.90 | SCN9A (0.97) | SCN9ACYP2D6MAOAMAPK1ADRA1A | |
| Lamotrigine SCHEMBL1401495 | 0.90 | SCN9A (0.97) | SCN9ACYP2D6MAOAMAPK1ADRA1A | |
| Lamotrigine SCHEMBL3976546 | 0.90 | SCN9A (0.97) | SCN9ACYP2D6MAOAMAPK1ADRA1A | |
| Lamotrigine SCHEMBL3167376 | 0.90 | SCN9A (0.97) | SCN9ACYP2D6MAOAMAPK1ADRA1A | |
| Lamotrigine SCHEMBL4142403 | 0.90 | SCN9A (0.97) | SCN9ACYP2D6MAOAMAPK1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1390355-A4 | NEW CRYSTAL FORMS OF LAMOTRIGINE AND PROCESSES FOR THEIR PREPARATIONS | TEVA PHARMA (IL) | 2005-02-23 | — | — | EP | disclosed |
| EP-1390355-A2 | NEW CRYSTAL FORMS OF LAMOTRIGINE AND PROCESSES FOR THEIR PREPARATIONS | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2004-02-25 | — | — | EP | disclosed |
| WO-2002068398-A1 | NEW CRYSTAL FORMS OF LAMOTRIGINE AND PROCESSES FOR THEIR PREPARATIONS | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2002-09-06 | — | — | WO | disclosed |