SCHEMBL6138380

SCHEMBL6138380

CC(C)[C@H](N)C(=O)NCCN1CCOCC1

nearest known ligand 0.77

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.59
ALDH1A1 P00352 2/20 0.54
TDP1 Q9NUW8 1/20 0.51
MAPT P10636 1/20 0.49
NPSR1 Q6W5P4 1/20 0.48
GAA P10253 1/20 0.47
CA12 O43570 1/20 0.46
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
CA9 Q16790 1/20 0.46
POLB P06746 1/20 0.46
KDM4E B2RXH2 1/20 0.46
LMNA P02545 1/20 0.46
TLR2 O60603 1/20 0.45
CD274 Q9NZQ7 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1726101 1.00 TSHR (0.59) TSHRALDH1A1TDP1MAPTNPSR1
SCHEMBL12310314 0.88 TSHR (0.62) TSHRALDH1A1TDP1MAPTNPSR1
SCHEMBL12310311 0.88 TSHR (0.62) TSHRALDH1A1TDP1MAPTNPSR1
SCHEMBL13573035 0.88 TSHR (0.62) TSHRALDH1A1TDP1MAPTNPSR1
SCHEMBL1723878 0.87 TSHR (0.59) TSHRALDH1A1TDP1MAPTNPSR1
SCHEMBL1724880 0.87 TSHR (0.59) TSHRALDH1A1TDP1MAPTNPSR1
SCHEMBL1723696 0.87 TSHR (0.59) TSHRALDH1A1TDP1MAPTNPSR1
SCHEMBL29859252 0.87 TSHR (0.59) TSHRALDH1A1TDP1MAPTNPSR1
SCHEMBL3631759 0.87 TSHR (0.59) TSHRALDH1A1TDP1MAPTNPSR1
SCHEMBL14353631 0.87 TSHR (0.59) TSHRALDH1A1TDP1MAPTNPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1283823-A4 NOVEL MMP-2/MMP-9 INHIBITORS SMITHKLINE BEECHAM CORP (US) 2005-07-27 EP claimed
EP-1283823-A1 NOVEL MMP-2/MMP-9 INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2003-02-19 EP claimed
WO-2001090047-A1 NOVEL MMP-2/MMP-9 INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2001-11-29 WO claimed