Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Leucine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 6/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | REN | P00797 | 1/20 | 0.35 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.35 |
| ▸ | ANPEP | P15144 | 2/20 | 0.34 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.34 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CTSC | P53634 | 1/20 | 0.33 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL7423648 | 0.87 | DPP4 (0.41) | GHSRSLC6A2SLC6A4SLC6A3ANPEP | |
| Leucine SCHEMBL6139042 | 0.86 | SLC7A5 (0.39) | GHSRSLC6A2SLC6A4SLC6A3REN | |
| Leucine SCHEMBL6534720 | 0.84 | SLC7A5 (0.46) | RENSLC7A5DPP4DPP8 | |
| Leucine SCHEMBL7110075 | 0.84 | SLC7A5 (0.46) | RENSLC7A5DPP4DPP8 | |
| Leucine SCHEMBL28334400 | 0.84 | SLC7A5 (0.46) | RENSLC7A5DPP4DPP8 | |
| Leucine SCHEMBL23091356 | 0.84 | SLC7A5 (0.49) | RENSLC7A5DPP4DPP8 | |
| Leucine SCHEMBL5889661 | 0.84 | SLC7A5 (0.49) | RENSLC7A5DPP4DPP8 | |
| Leucine SCHEMBL3089172 | 0.84 | SLC7A5 (0.49) | RENSLC7A5DPP4DPP8 | |
| Leucine SCHEMBL21382169 | 0.84 | SLC7A5 (0.49) | RENSLC7A5DPP4DPP8 | |
| Leucine SCHEMBL4612424 | 0.84 | SLC7A5 (0.49) | RENSLC7A5DPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1222242-B1 | CLEANING AGENTS WHICH CONTAIN SURFACTANTS AND ENZYME INHIBITORS | HENKEL KGAA (DE) | 2005-04-20 | — | — | EP | claimed |