⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13176095 | 0.71 | — | — | |
| SCHEMBL3063199 | 0.67 | EGLN1 (0.42) | — | |
| SCHEMBL18601715 | 0.67 | — | — | |
| SCHEMBL14611232 | 0.63 | — | — | |
| SCHEMBL3407661 | 0.63 | — | — | |
| SCHEMBL1640394 | 0.62 | — | — | |
| SCHEMBL7988956 | 0.62 | — | — | |
| SCHEMBL7591210 | 0.62 | — | — | |
| SCHEMBL297777 | 0.61 | — | — | |
| SCHEMBL4605189 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0300850-B1 | 1-ARYLSULFONYL-1,5-DIHYDRO 2H-PYRROL-2-ONE DERIVATIVES, INTERMEDIATES AND PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICINES AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1992-08-26 | — | — | EP | claimed |
| EP-0300850-A2 | 1-Arylsulfonyl-1,5-dihydro 2H-pyrrol-2-one derivatives, intermediates and process for their preparation, their use as medicines and compositions containing them | ROUSSEL-UCLAF (FR) | 1989-01-25 | — | — | EP | claimed |
| EP-3986896-A1 | EGFR INHIBITORS FOR THE TREATMENT OF CANCER | F. Hoffmann-La Roche AG (CH) | 2022-04-27 | — | — | EP | disclosed |
| EP-3313200-B1 | (5R)-(SS-D-GLUCOPYRANOSYLOXY)-1,5-DIHYDRO-2H-PYRROL-2-ONE AS UMAMI MOLECULE | NESTEC SA (CH) | 2019-04-03 | — | — | EP | disclosed |
| US-RE44778-E1 | Heterobifunctional pan-selectin inhibitors | GLYCOMIMETICS, INC. (US) | 2014-02-25 | — | — | US | disclosed |
| EP-1745078-B1 | METHOD FOR THE PURIFICATION OF ALBUMIN CONJUGATES | CONJUCHEM BIOTECHNOLOGIES INC (CA) | 2009-06-17 | — | — | EP | disclosed |
| EP-1511704-A1 | POLYMERISATION INHIBITOR | A H Marks & Company Limited (GB) | 2005-03-09 | — | — | EP | disclosed |
| WO-2003106390-A1 | POLYMERISATION INHIBITOR | A H MARKS & COMPANY LIMITED (GB) | 2003-12-24 | — | — | WO | disclosed |
| EP-0300850-B1 | 1-ARYLSULFONYL-1,5-DIHYDRO 2H-PYRROL-2-ONE DERIVATIVES, INTERMEDIATES AND PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICINES AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1992-08-26 | — | — | EP | disclosed |
| EP-0300850-A2 | 1-Arylsulfonyl-1,5-dihydro 2H-pyrrol-2-one derivatives, intermediates and process for their preparation, their use as medicines and compositions containing them | ROUSSEL-UCLAF (FR) | 1989-01-25 | — | — | EP | disclosed |